| Yazarlar |
Murtaza Emre Durakoğlugil
Recep Tayyip Erdoğan Üniversitesi, Türkiye |
|
Teslime Ayaz Özkan
Recep Tayyip Erdoğan Üniversitesi, Türkiye |
|
Kocaman Sinan Altan
|
Prof. Dr. Aynur KIRBAŞ
Recep Tayyip Erdoğan Üniversitesi, Türkiye |
|
Tuğba Durakoğlugil
Recep Tayyip Erdoğan Üniversitesi, Türkiye |
|
Turan Erdoğan
Recep Tayyip Erdoğan Üniversitesi, Türkiye |
|
Mustafa Çetin
Recep Tayyip Erdoğan Üniversitesi, Türkiye |
|
Yüksel Çiçek
Recep Tayyip Erdoğan Üniversitesi, Türkiye |
| Özet |
| Objective: Catestatin has several cardiovascular actions, in addition to diminished sympatho-adrenal flow. Decreased plasma catestatin levelsmay reflect a predisposition for the development of hypertension and metabolic disorders. We planned to investigate the possible roles ofcatestatin in untreated hypertensive patients. As a secondary objective, we compared catestatin concentrations of healthy subjects with thoseof hypertensive patients in order to understand whether catestatin is increased reactively or diminished at onset. Methods: Our study was cross-sectional and observational. The patient group, comprising 109 consecutive untreated hypertensive patientswithout additional systemic or coronary heart disease, underwent evaluations of plasma catestatin, waist circumference, lipid parameters, leftventricular mass, carotid intima-media thickness, and flow-mediated dilation of the brachial artery. Additionally, we measured catestatin con- centrations of 38 apparently healthy subjects without any disease using a commercial enzyme-linked immunosorbent assay kit. Results: We documented increased catestatin concentrations in previously untreated hypertensive patients compared to healthy controls (2.27±0.83vs. 1.92±0.49 ng/mL, p=0.004). However, this association became insignificant after adjustments for age, gender, height, and weight. Within the patientgroup, catestatin levels were significantly higher in females. Among all study parameters, age, high-density lipoprotein cholesterol (HDL-C) corre- lated positively to plasma catestatin, whereas triglycerides, hemoglobin, and left ventricular mass correlated negatively to plasma catestatin. Wecould not detect an association between vascular parameters and catestatin. Catestatin levels were significantly elevated with increasing HDL-C(1.91±0.37, 2.26±0.79, and 3.1±1.23 ng/mL in patients with HDL-C <40, 40-60, and >60 mg/dL, respectively). Multiple linear regression analysis revealedage (beta: 0.201, p=0.041) and HDL-C (beta: 0.390, p<0.001) as independent correlates of plasma catestatin concentration. Additionally, male gender(beta:-0.330, p=0.001) and plasma catestatin (beta: 0.299, p=0.002) were significantly associated with HDL-C concentrations. Conclusion: We documented that plasma catestatin is an independent predictor of high-density lipoprotein cholesterol. In addition to antihy- pertensive effects, catestatin appears to be related to improved lipid and metabolic profiles. Coexistence of low catestatin levels with lowHDL-C may provide a probable mechanism for the predictive value of low HDL-C for increased hypertension and cardiovascular events. |
| Anahtar Kelimeler |
| catestatin, hypertension, high-density lipoprotein cholesterol, sympatho-adrenal flow, low HDL-C |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale |
| Dergi Adı | ANATOLIAN JOURNAL OF CARDIOLOGY |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Makale Dili | İngilizce |
| Basım Tarihi | 01-2015 |
