The relationship of plasma catestatin concentrations with metabolic and vascular parameters in untreated hypertensive patients Influence on high density lipoprotein cholesterol
Yazarlar (9)
Murtaza Emre Durakoğlugil
Recep Tayyip Erdogan University, Türkiye
Recep Tayyip Erdogan University, Türkiye
Teslime Ayaz Recep Tayyip Erdogan University, Türkiye
Sinan Altan Kocaman
Recep Tayyip Erdogan University, Türkiye
Recep Tayyip Erdogan University, Türkiye
Prof. Dr. Aynur KIRBAŞ Recep Tayyip Erdogan University, Türkiye
Tuğba Durakoğlugil
Recep Tayyip Erdogan University, Türkiye
Recep Tayyip Erdogan University, Türkiye
Turan Erdoğan
Recep Tayyip Erdogan University, Türkiye
Recep Tayyip Erdogan University, Türkiye
Prof. Dr. Mustafa Çetin Recep Tayyip Erdogan University, Türkiye
Osman Zikrullah Şahin
Recep Tayyip Erdogan University, Türkiye
Recep Tayyip Erdogan University, Türkiye
Yüksel Çiçek
Recep Tayyip Erdogan University, Türkiye
Recep Tayyip Erdogan University, Türkiye
| Makale Türü |
Özgün Makale
(SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale)
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| Dergi Adı | Anadolu Kardiyoloji Dergisi | ||
| Dergi ISSN | 1302-8723 | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 01-2015 |
| Kabul Tarihi | – | Yayınlanma Tarihi | 06-03-2015 |
| Cilt / Sayı / Sayfa | 15 / 7 / 577–585 | DOI | 10.5152/akd.2014.5536 |
| Makale Linki | https://doi.org/10.5152/akd.2014.5536 | ||
| UAK Araştırma Alanları |
Kardiyoloji
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| Özet |
| Objective Catestatin has several cardiovascular actions, in addition to diminished sympatho-adrenal flow. Decreased plasma catestatin levels may reflect a predisposition for the development of hypertension and metabolic disorders. We planned to investigate the possible roles of catestatin in untreated hypertensive patients. As a secondary objective, we compared catestatin concentrations of healthy subjects with those of hypertensive patients in order to understand whether catestatin is increased reactively or diminished at onset. Methods Our study was cross-sectional and observational. The patient group, comprising 109 consecutive untreated hypertensive patients without additional systemic or coronary heart disease, underwent evaluations of plasma catestatin, waist circumference, lipid parameters, left ventricular mass, carotid intima-media thickness, and flow-mediated dilation of the brachial artery. Additionally, we measured catestatin concentrations of 38 apparently healthy subjects without any disease using a commercial enzyme-linked immunosorbent assay kit. Results We documented increased catestatin concentrations in previously untreated hypertensive patients compared to healthy controls (2.27±0.83 vs. 1.92±0.49 ng/mL, p= 0.004). However, this association became insignificant after adjustments for age, gender, height, and weight. Within the patient group, catestatin levels were significantly higher in females. Among all study parameters, age, high-density lipoprotein cholesterol (HDL-C) correlated positively to plasma catestatin, whereas triglycerides, hemoglobin, and left ventricular mass correlated negatively to plasma catestatin … |
| Anahtar Kelimeler |
| Catestatin | High-density lipoprotein cholesterol | Hypertension | Low HDL-C | Sympatho-adrenal flow |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 21 |
| Scopus | 28 |
| Google Scholar | 48 |