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Biologically active Schiff bases containing thiophene furan ring andtheir copper II complexes Synthesis spectral nonlinear optical and density functional studies      
Yazarlar
Ayla Balaban Gündüzalp
Gazi Üniversitesi, Türkiye
İffet Özsen
Hamit Alyar
Çankırı Karatekin Üniversitesi, Türkiye
Saliha Alyar
Prof. Dr. Neslihan ÖZBEK
Ahi Evran Üniversitesi, Türkiye
Özet
Schiff bases; 1,8-bis(thiophene-2-carboxaldimine)-p-menthane (L1) and 1,8-bis(furan-2-carboxaldimine)-p-menthane (L2) have been synthesized and characterized by elemental analysis, 1H-13C NMR, UV-vis, FT-IR and LC-MS methods. 1H and 13C shielding tensors for L1 and L2 were calculated with GIAO/DFT/B3LYP/6-311++G(d,p) methods in CDCl3. The vibrational band assignments, nonlinear optical (NLO) activities, frontier molecular orbitals (FMOs) and absorption spectrum have been investigated by the same basis set. Schiff base-copper(II) complexes have been synthesized and structurally characterized with spectroscopic methods, magnetic and conductivity measurements. The spectroscopic data suggest that Schiff base ligands coordinate through azomethine-N and thiophene-S/furan-O donors (as SNNS and ONNO chelating systems) to give a tetragonal geometry around the copper(II) ions. Schiff bases and Cu(II) complexes have been screened for their biological activities on different species of pathogenic bacteria, those are, Gram positive bacteria: Bacillus subtitilus, Yersinia enterotica, Bacillus cereus, Listeria monocytogenes, Micrococcus luteus and Gram negative bacteria: Escherichia coli, Pseudomonas aeroginosa, Shigella dysenteriae, Salmonella typhi, Klebsiella pseudomonas by using microdilution technique (MIC values in mM). Biological activity results show that Cu(II) complexes have higher activities than parent ligands and metal chelation may affect significantly the antibacterial behavior of the organic ligands.
Anahtar Kelimeler
Antibacterial activity | DFT method | NLO | Schiff base | Thiophene/furan aldehyde
Makale Türü Özgün Makale
Makale Alt Türü SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale
Dergi Adı JOURNAL OF MOLECULAR STRUCTURE
Dergi ISSN 0022-2860
Dergi Tarandığı Indeksler SCI
Makale Dili İngilizce
Basım Tarihi 01-2016
Cilt No 1120
Sayfalar 256 / 266
BM Sürdürülebilir Kalkınma Amaçları
Atıf Sayıları
WoS 44
SCOPUS 45
Google Scholar 53

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