| Yazarlar |
Ayla Şahin
|
Dr. Öğr. Üyesi Gözde EKE ÇEVİK
Türkiye |
|
Arda Büyüksungur
Ankara Üniversitesi, Türkiye |
|
Vasıf Nejat Hasırcı
Acıbadem Mehmet Ali Aydınlar Üniversitesi, Türkiye |
|
Nesrin Hasırcı
Yakın Doğu Üniversitesi, Türkiye |
| Özet |
| The aim of this study was to target nano sized (266 +/- 25nm diameter) poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) particles carrying Doxorubicin (DOX), an anticancer agent, to human osteosarcoma cells (Saos-2). A nuclear targeting molecule (Nuclear Localization Signal, NLS), a 17 a.a. peptide, was attached onto the doxorubicin loaded nanoparticles. NLS conjugated nanoparticles surrounded the cell nuclei, but did not penetrate them. Free doxorubicinand doxorubicin loadednanoparticles entered the cytoplasm and were evenly distributed within the cytoplasm. The localization of the NLS-targetedparticles around the nuclear membrane caused a significantly higher decrease in the cancer cell numbers due to apoptosis or necrosis than the untargeted and free doxorubicin formulations showing the importance of targeting the nanoparticles to the nuclear membrane in the treatment of cancer. |
| Anahtar Kelimeler |
| PHBV | biodegradable nanoparticles | nuclear drug delivery | doxorubicin | nuclear localization signal |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale |
| Dergi Adı | JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION |
| Dergi ISSN | 0920-5063 |
| Dergi Tarandığı Indeksler | SCI |
| Makale Dili | Türkçe |
| Basım Tarihi | 01-2018 |
| Cilt No | 29 |
| Sayı | 5 |
| Sayfalar | 507 / 519 |
| Doi Numarası | 10.1080/09205063.2018.1423812 |
| Atıf Sayıları | |
| WoS | 16 |
