A prospective, randomized, double-blind, placebo-controlled trial of glyceryl-trinitrate ointment in the treatment of children with anal fissure
Yazarlar (6)
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | JOURNAL OF PEDIATRIC SURGERY (Q2) | ||
| Dergi ISSN | 0022-3468 Dergi Bilgileri (1999) | ||
| Makale Dili | İngilizce | Basım Tarihi | 12-1999 |
| Cilt / Sayı / Sayfa | 34 / 12 / 1810–1812 | DOI | 10.1016/S0022-3468(99)90318-4 |
| Makale Linki | https://www.sciencedirect.com/science/article/pii/S0022346899903184 | ||
| UAK Araştırma Alanları |
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| Özet |
| Background Anal fissure in children usually is treated by sitz baths, stool softeners, and analgesic ointments. However, some cases are intractable to the treatment. In recent years, it has been reported that nitric oxide donors such as local glyceryl-trinitrate (GTN) ointment causes a reversible chemical sphincterotomy. Although the GTN ointment can be an alternative therapy for adult cases, it has not yet been studied in the children who suffer from anal fissure. Methods Sixty-five children with anal fissure were divided randomly into 3 groups. Each group received double-blinded a topical ointment that contained either 0.2% GTN, 10% lidocain, or placebo. These ointments were applied to the lowest part of the anal canal twice daily. Patients were periodically reviewed, and the study was ended after 8 weeks. Results Complete healing of the fissure occurred in 26 of 31 (83.9%) patients treated with GTN, 7 of 14 (50 … |
| Anahtar Kelimeler |
| anal fissure | nitric oxide | glyceryl trinitrate |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 32 |
| Google Scholar | 74 |