IL-17A, IL-17RA, and IL-22 as biomarkers in migraine: associations with disease activity and clinical features
Yazarlar (4)
Dr. Öğr. Üyesi Gamze TURNA SALTOĞLU Kırşehir Ahi Evran Üniversitesi, Türkiye
Prof. Dr. Serap YALÇIN AZARKAN Kırşehir Ahi Evran Üniversitesi, Türkiye
Dr. Öğr. Üyesi Aydan KÖYSÜREN Kırşehir Ahi Evran Üniversitesi, Türkiye
Asuman Celikbilek
Kırşehir Ahi Evran Üniversitesi, Türkiye
Kırşehir Ahi Evran Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Irish Journal of Medical Science (Q2) | ||
| Dergi ISSN | 0021-1265 Dergi Bilgileri (2026) | ||
| Makale Dili | İngilizce | Basım Tarihi | 01-2026 |
| Cilt / Sayı / Sayfa | 0 / 1 / – | DOI | 10.1007/s11845-026-04538-1 |
| Makale Linki | https://link.springer.com/article/10.1007/s11845-026-04538-1 | ||
| UAK Araştırma Alanları |
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| Özet |
| BackgroundMigraine is increasingly recognized as a neuroinflammatory disorder involving immune-mediated mechanisms. Th17-related cytokines, including interleukin-17 A (IL-17 A) and interleukin-22 (IL-22), together with the IL-17 receptor A (IL-17RA), may contribute to these processes; however, their clinical relevance remains incompletely understood. This study aimed to assess their levels in patients with migraine and to investigate their associations with clinical characteristics.MethodsNinety-nine patients with migraine and 50 healthy controls were included. Serum IL-17 A, IL-17RA, and IL-22 levels were measured using the enzyme-linked immunosorbent assay (ELISA), and their relationships with clinical features were analyzed.ResultsSerum levels of IL-17 A, IL-17RA, and IL-22 were significantly higher in patients with migraine compared to healthy controls (p< 0.05 for all). IL-22 levels were positively … |
| Anahtar Kelimeler |
| Biomarkers | IL-17A | IL-17RA | IL-22 | Migraine | Neuroinflammation |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Scopus | 1 |