Is there a familial predisposition to bisphosphonate-induced atypical femoral fractures?
       
Yazarlar (4)
Mehmet Okçu
Kırşehir Ahi Evran Üniversitesi, Türkiye
Fatmanur Aybala Koçak
Kırşehir Ahi Evran Üniversitesi, Türkiye
Samet Sancar Kaya
Kırşehir Ahi Evran Üniversitesi, Türkiye
Prof. Dr. Figen TUNCAY Kırşehir Ahi Evran Üniversitesi, Türkiye
Makale Türü Açık Erişim Diğer (Teknik, not, yorum, vaka takdimi, editöre mektup, özet, kitap krıtiği, araştırma notu, bilirkişi raporu ve benzeri) (SCI, SSCI, AHCI, SCI-Exp dergilerinde yayınlanan teknik not, editöre mektup, tartışma, vaka takdimi ve özet türünden makale)
Dergi Adı Turkish Journal of Physical Medicine and Rehabilitation
Dergi ISSN 2587-0823
Dergi Tarandığı Indeksler SCI-Expanded
Makale Dili İngilizce Basım Tarihi 10-2021
Cilt / Sayı / Sayfa 67 / 3 / 370–373 DOI 10.5606/tftrd.2021.5248
Makale Linki https://www.ftrdergisi.com/uploads/pdf/pdf_4190.pdf
Özet
Bisphosphonates are commonly used in the treatment of osteoporosis. Atypical femoral fracture (AFF) is a well-known adverse effect
of bisphosphonate use. The importance of genetic factors has been demonstrated in bone quality, bone turnover, and in the response to
osteoporosis treatment. Herein, we present two cases of bilateral AFFs after bisphosphonate use for a short period of time in members of the
same family (mother and her daughter) and discuss genetic predisposition to bisphosphonate-induced AFFs in the light of literature data.
Anahtar Kelimeler
Atypical femoral fracture | Bisphosphonate | Genetic factors