| Yazarlar (5) |
Mustafa Nisari
Nuh Naci Yazgan Üniversitesi, Türkiye |
|
Memet Hanifi Emre
Bahçeşehir Üniversitesi, Türkiye |
|
Nazan Dolu
Başkent Üniversitesi, Türkiye |
|
Hale Acer
|
Dr. Öğr. Üyesi Ferhat PEKTAŞ
Kırşehir Ahi Evran Üniversitesi, Türkiye |
| Özet |
| Aim Propolis has been shown to have anti-microbial, antioxidant, anti-tumor, anxiolytic and anti-inflammatory effects. However, to the best of our knowledge, there are no studies on its anxiogenic effects. In this study, we aimed to investigate the effects of different doses of propolis on anxiety in rats with cold stress via sympathetic skin response (electrodermal activity) and elevated T maze.Methods Forty Wistar albino male rats were used in the study, divided into four groups: The control group, low dose (10 mg/kg PRO), medium dose (30 mg/kg PRO) and high dose propolis groups (50 mg/kg PRO). Propolis was administered via gavage to all rats except the control group. Twenty minutes after injection, the anxiety scores of the rats were evaluated with an elevated T-maze, and their electrodermal activities (EDA) were measured. At the end of the experiment, some enzymatic and lipid values were measured with malondialdehyde (MDA) in blood samples.Results The percentage of time spent on open arms and the number of open arm entries were lower in the 10mg/kg PRO group, while an increase was observed in the 30 mg/kg PRO group. EDA values were lower in the 30 mg / kg PRO (P=0.012; P=0.02, respectively) and 50 mg / kg PRO (P=0.013, P=0.02, respectively) groups as compared to the control group. MDA was significantly lower in the 30 mg/kg PRO and 50 mg/kg PRO groups. While AST value increased in the 30 mg / kg PRO group, ALT value decreased. Total cholesterol and triglyceride values were significantly lower in the 50 mg / kg PRO group. HDL value increased significantly after administration of propolis and LDL value … |
| Anahtar Kelimeler |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | Uluslararası alan indekslerindeki dergilerde yayınlanan tam makale |
| Dergi Adı | Journal of Surgery and Medicine |
| Dergi ISSN | 2602-2079 |
| Dergi Tarandığı Indeksler | CrossRef (DOI), Academic Keys, International Society for Research Activity (ISRA), ResearchBib, International Scientific Indexing (ISI), Directory of Research Journals Indexing (DRJI), International Institute of Organized Researches (I2OR), Science Library Index, Journal Factor, scientific World Index (SCIWIN), General Impact Factor, Journal Impact Factor (JIFACTOR), Scientific Indexing Service (SIS), J-Gate, Rootindexing, SHERPA/RoMEO, COSMOS IF, International Committee of Medical Journal Editors (ICMJE), ROAD, CiteFactor, Bielefeld Academic Search Engine (BASE) |
| Makale Dili | İngilizce |
| Basım Tarihi | 05-2020 |
| Cilt No | 4 |
| Sayı | 5 |
| Sayfalar | 346 / 350 |
| Makale Linki | https://dergipark.org.tr/en/doi/10.28982/josam.726017 |
