Molecular characterization of the influenza A(H1N1)pdm09 isolatescollected in the 2015‐2016 season and comparison of HA mutations detected in Turkey since 2009
Yazarlar (9)
Dilek Güldemir
T.C. Sağlık Bakanlığı,, Türkiye
Prof. Dr. Fatma Filiz ARI
Kırşehir Ahi Evran Üniversitesi, Türkiye
Ayse Basak Altas
T.C. Sağlık Bakanlığı,, Türkiye
Zekiye Bakkaloglu
T.C. Sağlık Bakanlığı,, Türkiye
Özlem Ünaldı
T.C. Sağlık Bakanlığı,, Türkiye
Fatma Bayraktar
T.C. Sağlık Bakanlığı,, Türkiye
Gulay Korukluoglu
T.C. Sağlık Bakanlığı,, Türkiye
Ali Riza Aktas
T.C. Sağlık Bakanlığı,, Türkiye
Rıza Durmaz
Ankara Yildirim Beyazit University, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Journal of Medical Virology (Q4) | ||
| Dergi ISSN | 0146-6615 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 08-2019 |
| Cilt / Sayı / Sayfa | 91 / 12 / 2074–2082 | DOI | 10.1002/jmv.25565 |
| Özet |
| Influenza A(H1N1)pdm09 pandemic virus causing the 2009 global outbreak moved into the post-pandemic period, but its variants continued to be the prevailing subtype in the 2015-2016 influenza season in Europe and Asia. To determine the molecular characteristics of influenza A(H1N1)pdm09 isolates circulating during the 2015-2016 season in Turkey, we identified mutations in the hemagglutinin (HA) genes and investigated the presence of H275Y alteration in the neuraminidase genes in the randomly selected isolates. The comparison of the HA nucleotide sequences revealed a very high homology (>99.5%) among the studied influenza A(H1N1)pdm09 isolates, while a relatively low homology (96.6%-97.2%), was observed between Turkish isolates and the A/California/07/2009 vaccine virus. Overall 14 common mutations were detected in HA sequences of all 2015-2016 influenza A(H1N1)pdm09 isolates with respect to the A/California/07/2009 virus, four of which located in three different antigenic sites. Eleven rare mutations in 12 HA sequences were also detected. Phylogenetic analysis revealed that all characterized influenza A(H1N1)pdm09 isolates formed a single genetic cluster, belonging to the genetic subclade 6B.1, defined by HA amino acid substitutions S84N, S162N, and I216T. Furthermore, all isolates showed an oseltamivir-sensitive genotype, suggesting that Tamiflu (Oseltamivir) could still be the drug of choice in Turkey. |
| Anahtar Kelimeler |
| 2015-2016 influenza season | hemagglutinin | influenza A(H1N1)pdm09 | neuraminidase | oseltamivir resistance |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| WoS | 4 |
| SCOPUS | 3 |