Nasopharyngeal pneumococcal carriage in healthy Turkish children after 13-valent conjugated pneumococcal vaccine implementation in the national immunization program
Yazarlar (13)
Saliha Kanık Yüksek
Ankara Children's Hematology Oncology Training And Research Hospital, Türkiye
Hasan Tezer
Gazi University, Faculty Of Medicine, Türkiye
Belgin Gülhan
Ankara Children's Hematology Oncology Training And Research Hospital, Türkiye
Aslınur Özkaya Parlakay
Ankara Children's Hematology Oncology Training And Research Hospital, Türkiye
Dilek Güldemir
T.C. Sağlık Bakanlığı,, Türkiye
Prof. Dr. Fatma Filiz ARI
Kırşehir Ahi Evran Üniversitesi, Türkiye
Tuğba Bedir Demirdağ
Gazi University, Faculty Of Medicine, Türkiye
Aysun Kara Uzun
Ankara Children's Hematology Oncology Training And Research Hospital, Türkiye
Murat Kızılgün
Ankara Children's Hematology Oncology Training And Research Hospital, Türkiye
Sinem Solmaz
Gazi University, Faculty Of Medicine, Türkiye
Selçuk Kılıç
T.C. Sağlık Bakanlığı,, Türkiye
Meltem Yalınay Çırak
Gazi University, Faculty Of Medicine, Türkiye
Fatma Nur Baran Aksakal
Gazi University, Faculty Of Medicine, Türkiye
| Makale Türü |
Özgün Makale
(SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale)
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| Dergi Adı | Journal of Infection and Public Health (Q4) | ||
| Dergi ISSN | 1876-0341 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | Türkçe | Basım Tarihi | 02-2020 |
| Cilt / Sayı / Sayfa | 13 / 2 / 266–274 | DOI | 10.1016/j.jiph.2019.10.009 |
| Makale Linki | http://dx.doi.org/10.1016/j.jiph.2019.10.009 | ||
| Özet |
| Background: In Turkey, pneumococcal conjugated vaccine (PCV) was introduced to the national immunization program as PCV7 in 2008, and was replaced with PCV13 in 2011. The aims of this study were to investigate the effects of PCV13 on nasopharyngeal pneumococcal carriage (NPC) by determining the serotype distribution, and to identify risk factors for carriage, in healthy Turkish children. Methods: This prospective study was conducted on 500 healthy children aged 0–13 years between April and November 2014. Nasopharyngeal swab samples were taken, and molecular method for capsular serotyping was performed by multiplex PCR. Results: Of 500 children, 43.4% were unvaccinated with a PCV (7- or 13-valent), 56.6% were vaccinated and The NPC rate was found to be 9.8%. Of 49 positive Streptococcus pneumoniae isolates, 26 (53%) were PCV13 vaccine strains (VSs), and 17 (34.7%) were non-VS. Six isolates (12.2%) were not typeable by the method applied. The most common serotypes detected were serotype 3 (18.3%), serotype 19F (14.2%), serotype 6A/B (8.1%), serotype 11A (8.1%), and serotype 15B (8.1%). The total coverage rate of the PCV13 serotypes was 60.4%. Conclusion: A significant decrease in carriage rate was detected within three years after the introduction of PCV13 in Turkey. However, the nasopharyngeal carriage of PCV13 strains was found to be interestingly high. |
| Anahtar Kelimeler |
| Healthy children | Nasopharyngeal carriage | PCV13 | Pneumococcal conjugated vaccine | Serotyping |
Science Direct
Nasopharyngeal pneumococcal carriage in healthy Turkish children after 13-valent conjugated pneumococcal vaccine implementation in the national immunization program
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| WoS | 8 |
| SCOPUS | 9 |