| Yazarlar (13) |
Saliha Kanık Yüksek
Türkiye |
|
Hasan Tezer
Türkiye |
|
Belgin Gülhan
|
|
Aslınur Özkaya Parlakay
|
|
Dilek Güldemir
Türkiye |
Prof. Dr. Fatma Filiz ARI
Kırşehir Ahi Evran Üniversitesi, Türkiye |
|
Tuğba Bedir Demirağ
|
|
Aysun Kara Uzun
|
|
F Nur Aksakal
|
|
Sinem Solmaz
|
|
Selçuk Kılıç
Sağlık Bilimleri Üniversitesi, Türkiye |
|
Ateş Kara
Hacettepe Üniversitesi, Türkiye |
|
Ayşe Meltem Yalınay
Türkiye |
| Özet |
| Background: In Turkey, pneumococcal conjugated vaccine (PCV) was introduced to the national immunization program as PCV7 in 2008, and was replaced with PCV13 in 2011. The aims of this study were to investigate the effects of PCV13 on nasopharyngeal pneumococcal carriage (NPC) by determining the serotype distribution, and to identify risk factors for carriage, in healthy Turkish children. Methods: This prospective study was conducted on 500 healthy children aged 0–13 years between April and November 2014. Nasopharyngeal swab samples were taken, and molecular method for capsular serotyping was performed by multiplex PCR. Results: Of 500 children, 43.4% were unvaccinated with a PCV (7- or 13-valent), 56.6% were vaccinated and The NPC rate was found to be 9.8%. Of 49 positive Streptococcus pneumoniae isolates, 26 (53%) were PCV13 vaccine strains (VSs), and 17 (34.7%) were non-VS. Six isolates (12.2%) were not typeable by the method applied. The most common serotypes detected were serotype 3 (18.3%), serotype 19F (14.2%), serotype 6A/B (8.1%), serotype 11A (8.1%), and serotype 15B (8.1%). The total coverage rate of the PCV13 serotypes was 60.4%. Conclusion: A significant decrease in carriage rate was detected within three years after the introduction of PCV13 in Turkey. However, the nasopharyngeal carriage of PCV13 strains was found to be interestingly high. |
| Anahtar Kelimeler |
| Healthy children | Nasopharyngeal carriage | PCV13 | Pneumococcal conjugated vaccine | Serotyping |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale |
| Dergi Adı | J Infect Public Health |
| Dergi ISSN | 1876-0341 Wos Dergi Scopus Dergi |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Dergi Grubu | Q4 |
| Makale Dili | Türkçe |
| Basım Tarihi | 02-2020 |
| Cilt No | 13 |
| Sayı | 1 |
| Sayfalar | 266 / 274 |
| Doi Numarası | 10.1016/j.jiph.2019.10.009 |
| Makale Linki | http://dx.doi.org/10.1016/j.jiph.2019.10.009 |
| Atıf Sayıları | |
| SCOPUS | 8 |
