One-Step Microfluidic Coating of Phospholipid Microbubbles with Natural Alginate Polymer as a Delivery System for Human Epithelial Lung Adenocarcinoma
Yazarlar (6)
Dr. Öğr. Üyesi Esra İLHAN Kırşehir Ahi Evran Üniversitesi, Türkiye
Pelin Saglam-Metiner
Ege Üniversitesi, Türkiye
Ege Üniversitesi, Türkiye
Giuliana Manzi
Tide Microfluidics, Hollanda
Tide Microfluidics, Hollanda
Katharine Giannasi Tide Microfluidics, Hollanda
Wim Van Hoeve Tide Microfluidics, Hollanda
Ozlem Yesil-Celiktas Ege Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Macromolecular Bioscience (Q1) | ||
| Dergi ISSN | 1616-5187 Dergi Bilgileri (2020) | ||
| Dergi Tarandığı Indeksler | SCI | ||
| Makale Dili | İngilizce | Basım Tarihi | 06-2020 |
| Kabul Tarihi | – | Yayınlanma Tarihi | 29-04-2020 |
| Cilt / Sayı / Sayfa | 20 / 6 / 2000084–0 | DOI | 10.1002/mabi.202000084 |
| Makale Linki | https://onlinelibrary.wiley.com/doi/10.1002/mabi.202000084 | ||
| UAK Araştırma Alanları |
Biyoteknoloji
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| Özet |
| In this study, the neoplastic drug frequently used in the treatment of lung cancer, carboplatin is loaded to microbubbles via a microfluidic platform. In order to increase the drug loading capacity of microbubbles, carboplatin is encapsulated into alginate polymer layer. The phospholipid microbubbles (MBs) are synthesized by MicroSphere Creator, which is connected with T‐junction and micromixer for the treatment with CaCl2 solution to provide gelation of the alginate coated phospholipid microbubbles (AMBs). The carboplatin loaded alginate coated phospholipid microbubbles (CAMBs) result in 12.2 ± 0.21 µm mean size, obtained by mixing with 0.05% CaCl2 using T‐junction. The cytotoxic activities of the synthesized MBs, AMBs, and CAMBs are also investigated with the 3‐(4,5‐Dimethyl‐2‐thiazolyl)‐2,5‐diphenyl‐2H‐tetrazolium bromide) (MTT) and live/dead fluorescent dying assays in the A549 and BEAS‐2B … |
| Anahtar Kelimeler |
| alginate | carboplatin | drug delivery | lung cancer | microbubbles | microfluidic |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 5 |
| Scopus | 6 |
| Google Scholar | 4 |