| Yazarlar (6) |
Dr. Öğr. Üyesi Esra İLHAN AYIŞIĞI
Kırşehir Ahi Evran Üniversitesi, Türkiye |
Fulden Ulucan
Ege Üniversitesi, Türkiye |
|
Ecem Saygılı
Ege Üniversitesi, Türkiye |
|
Pelin Saglam Metiner
Ege Üniversitesi, Türkiye |
|
Sultan Gulce‐Iz
Ege Üniversitesi, Türkiye |
|
Özlem Yeşil Çeliktaş
Ege Üniversitesi, Türkiye |
| Özet |
| BACKGROUND Propolis exhibits therapeutic properties due to the presence of phenolic acids, esters, and flavonoids. The scope of this study was to develop a nano-vesicular formulation and establish a three-dimensional (3D) spheroid model in which lung cancer is recapitulated. RESULTS Niosome vesicles doped with galangin-rich propolis extract were synthesized by the ether injection method using a cholesterol : surfactant mass ratio of 1 : 3 at 40 degrees C for 1 h. Formulated niosomes were administered to 3D lung cancer spheroid model and the cytotoxicity was compared with that of a two-dimensional (2D) setting. The galangin content was determined as 86 mu g mg(-1) propolis extract by ultra-performance liquid chromatography (UPLC). The particle size of loaded niosome was 151 +/- 2.84 nm with a polydispersity index (PDI) of about 0.232, and an encapsulation efficiency of 70% was achieved. CONCLUSION The decrease in cell viability and the scattering in the 3D spheroids of A549 lung cancer cells treated with propolis-loaded niosomes were notable, indicating a profound cytotoxic effect and suggesting that they can be utilized as an effective nano-vesicle. (c) 2020 Society of Chemical Industry |
| Anahtar Kelimeler |
| 3D cell culture | galangin | lung cancer | niosome | propolis |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale |
| Dergi Adı | JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE |
| Dergi ISSN | 0022-5142 Wos Dergi Scopus Dergi |
| Dergi Tarandığı Indeksler | SCI |
| Makale Dili | İngilizce |
| Basım Tarihi | 06-2020 |
| Cilt No | 100 |
| Sayı | 8 |
| Sayfalar | 3525 / 3535 |
| Doi Numarası | 10.1002/jsfa.10400 |
| Makale Linki | https://onlinelibrary.wiley.com/doi/abs/10.1002/jsfa.10400 |
| Atıf Sayıları | |
| WoS | 39 |
| SCOPUS | 40 |
| Google Scholar | 47 |
