Synthesis of an injectable heparin conjugated poloxamer hydrogel with high elastic recoverability for temporomandibular joint disorders
Yazarlar (7)
Buse Deliogullari
Ege Üniversitesi, Türkiye
Ege Üniversitesi, Türkiye
Dr. Öğr. Üyesi Esra İLHAN Kırşehir Ahi Evran Üniversitesi, Türkiye
Dr. Öğr. Üyesi Betul Cakmak Ege University Faculty of Engineering, Türkiye
Pelin Saglam-Metiner
Ege University Faculty of Engineering, Türkiye
Ege University Faculty of Engineering, Türkiye
Doç. Dr. Nusret Kaya İzmir Kâtip Çelebi Üniversitesi, Türkiye
Gulcan Coskun-Akar
Ege Üniversitesi, Türkiye
Ege Üniversitesi, Türkiye
Ozlem Yesil-Celiktas
Ege Üniversitesi, Türkiye
Ege Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Journal of Applied Polymer Science (Q2) | ||
| Dergi ISSN | 0021-8995 Dergi Bilgileri (2022) | ||
| Dergi Tarandığı Indeksler | SCI | ||
| Makale Dili | İngilizce | Basım Tarihi | 08-2022 |
| Kabul Tarihi | 29-05-2022 | Yayınlanma Tarihi | 09-06-2022 |
| Cilt / Sayı / Sayfa | 139 / 31 / – | DOI | 10.1002/app.52736 |
| Makale Linki | https://onlinelibrary.wiley.com/doi/10.1002/app.52736 | ||
| UAK Araştırma Alanları |
Biyoteknoloji
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| Özet |
| The temporomandibular joint (TMJ) is commonly affected during fundamental oral activities, reducing the quality of life. Herein, we synthesized a heparin‐conjugated poloxamer hydrogel (HEP) as a thermo‐responsive injectable hydrogel for the treatment of TMJ disorders. While the gelation temperature of synthesized HEP (25% [w/v]) was 29.8–30.0°C, there was a slight difference between loss and storage modulus. HEP decreased the friction of the TMJ, thus requires less energy during load‐bearing jaw movement in comparison to POL. Moreover, the oscillation test dependent on strain ranges from 0.01% to 1000% validated that POL and HEP3 hydrogels showed a similar critical strain of about 5.6%. The total elastic recovery percentage of HEP3 (53.50%) was higher than POL (45.55%), indicating a better recovery of the deformed hydrogel structure. Along with the suitable viscoelastic properties for … |
| Anahtar Kelimeler |
| heparin | injectable hydrogel | poloxamer | temperature sensitive gelation | temporomandibular joint | viscoelastic characterization |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 4 |
| Scopus | 5 |
| Google Scholar | 7 |