Usefulness of Tp-Te interval and Tp-Te/QT ratio in the prediction of ventricular arrhythmias and mortality in acute STEMI patients undergoing fibrinolytic therapy
Yazarlar (2)
Kırşehir Ahi Evran Üniversitesi, Türkiye
Prof. Dr. Erdoğan SÖKMEN
Kırşehir Ahi Evran Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | JOURNAL OF ELECTROCARDIOLOGY (Q4) | ||
| Dergi ISSN | 0022-0736 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI | ||
| Makale Dili | İngilizce | Basım Tarihi | 09-2019 |
| Cilt / Sayı / Sayfa | 56 / 0 / 100–105 | DOI | 10.1016/j.jelectrocard.2019.07.004 |
| Makale Linki | https://linkinghub.elsevier.com/retrieve/pii/S0022073619302729 | ||
| Özet |
| Background and aim: Acute ST-elevation myocardial infarction (STEW) is associated with fatal and non-fatal ventricular arrhythmic events (VAE). Although primary percutaneous intervention (PCI) is first-line treatment in STEMI, fibrinolytic therapy (FT) is still widely used in many countries. Tp-Te interval; Tp-Te/QT ratio and QT dispersion (QTd) are novel markers of ventricular repolarization (VR) and associate with VAE and mortality. Hereby, we assessed Tp-Te, QTd and Tp-Te/QT in acute STEMI patients undergoing FT and analyzed their relationship with post-FT VAE, and arrhythmic and overall deaths. Methods: A total of 207 consecutive STEM! patients treated with FT were retrospectively evaluated. Patients were divided in Group 1 (non-VAE group) and Group 2 (VAE group). ECG, clinical and demographic data were noted. Relationship between the pre-FT electrocardiographic parameters of VR and post-FT VAE, arrhythmic and overall death was evaluated. Results: Tp-Te, Tp-Te/QT and QTd were significantly higher in Group 2 compared to Group 1 (p < 0.05). Tp-Te, TpTe/QT, QTd, QTc and left ventricular ejection fraction (LVEF) predicted VAE. Tp-Te/QT and LVEF predicted arrhythmic death (1.05; 95% CI 1.01-1.08; p = 0.031 and 0.87; 95% CI 0.72-0.96; p = 0.040; respectively). In ROC analysis, cut-off for Tp-Te/QT to predict VAE was >0305 with 87.5% sensitivity and 60.1% specificity (AUC: 0.90; 95% Cl: 0.85-0.95; p < 0.001), and to predict arrhythmic death was >0.315 with 83.3% sensitivity and 62% specificity (AUC: 0.70; 95% CI: 0.60-0.81; p = 0.018). Conclusion: Tp-Te, Tp-Te/QT, QTc, QTd and LVEF are independent predictors of post-FT VAE in acute STEMI. Tp-Te/QT ratio is associated with VA-related deaths. (C) 2019 Elsevier Inc. All rights reserved. |
| Anahtar Kelimeler |
| Ventricular arrhythmia | Acute myocardial infarction | Fibrinolytic therapy | Prognosis |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| WoS | 9 |
| Google Scholar | 19 |