| Yazarlar (2) |
Sinan Cemgil Özbek
Kırşehir Ahi Evran Üniversitesi, Türkiye |
Doç. Dr. Erdoğan SÖKMEN
Kırşehir Ahi Evran Üniversitesi, Türkiye |
| Özet |
| Background and aim: Acute ST-elevation myocardial infarction (STEW) is associated with fatal and non-fatal ventricular arrhythmic events (VAE). Although primary percutaneous intervention (PCI) is first-line treatment in STEMI, fibrinolytic therapy (FT) is still widely used in many countries. Tp-Te interval; Tp-Te/QT ratio and QT dispersion (QTd) are novel markers of ventricular repolarization (VR) and associate with VAE and mortality. Hereby, we assessed Tp-Te, QTd and Tp-Te/QT in acute STEMI patients undergoing FT and analyzed their relationship with post-FT VAE, and arrhythmic and overall deaths. Methods: A total of 207 consecutive STEM! patients treated with FT were retrospectively evaluated. Patients were divided in Group 1 (non-VAE group) and Group 2 (VAE group). ECG, clinical and demographic data were noted. Relationship between the pre-FT electrocardiographic parameters of VR and post-FT VAE, arrhythmic and overall death was evaluated. Results: Tp-Te, Tp-Te/QT and QTd were significantly higher in Group 2 compared to Group 1 (p < 0.05). Tp-Te, TpTe/QT, QTd, QTc and left ventricular ejection fraction (LVEF) predicted VAE. Tp-Te/QT and LVEF predicted arrhythmic death (1.05; 95% CI 1.01-1.08; p = 0.031 and 0.87; 95% CI 0.72-0.96; p = 0.040; respectively). In ROC analysis, cut-off for Tp-Te/QT to predict VAE was >0305 with 87.5% sensitivity and 60.1% specificity (AUC: 0.90; 95% Cl: 0.85-0.95; p < 0.001), and to predict arrhythmic death was >0.315 with 83.3% sensitivity and 62% specificity (AUC: 0.70; 95% CI: 0.60-0.81; p = 0.018). Conclusion: Tp-Te, Tp-Te/QT, QTc, QTd and LVEF are independent predictors of post-FT VAE in acute STEMI. Tp-Te/QT ratio is associated with VA-related deaths. (C) 2019 Elsevier Inc. All rights reserved. |
| Anahtar Kelimeler |
| Ventricular arrhythmia | Acute myocardial infarction | Fibrinolytic therapy | Prognosis |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale |
| Dergi Adı | JOURNAL OF ELECTROCARDIOLOGY |
| Dergi ISSN | 0022-0736 Wos Dergi Scopus Dergi |
| Dergi Tarandığı Indeksler | SCI |
| Dergi Grubu | Q4 |
| Makale Dili | İngilizce |
| Basım Tarihi | 09-2019 |
| Cilt No | 56 |
| Sayfalar | 100 / 105 |
| Doi Numarası | 10.1016/j.jelectrocard.2019.07.004 |
| Makale Linki | https://linkinghub.elsevier.com/retrieve/pii/S0022073619302729 |
| Atıf Sayıları | |
| WoS | 9 |
