Relationship of growth differentiation factor-15 with aortic stiffness in essential hypertension
Yazarlar (5)
Prof. Dr. Erdoğan SÖKMEN
Kırşehir Ahi Evran Üniversitesi, Türkiye
Kırşehir Ahi Evran Üniversitesi, Türkiye
Kirsehir Ahi Evran University, Türkiye
Kırşehir Ahi Evran Üniversitesi, Türkiye
Kirsehir Ahi Evran University, Türkiye
| Makale Türü |
Özgün Makale
(ESCI dergilerinde yayınlanan tam makale)
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| Dergi Adı | FUTURE SCIENCE OA | ||
| Dergi ISSN | 2056-5623 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | Emerging Sources Citation Index (Web of Science) | ||
| Makale Dili | İngilizce | Basım Tarihi | 08-2019 |
| Cilt / Sayı / Sayfa | 5 / 7 / 406–0 | DOI | 10.2144/fsoa-2019-0029 |
| Makale Linki | https://www.future-science.com/doi/10.2144/fsoa-2019-0029 | ||
| Özet |
| Aim: We aimed to assess the relationship between echocardiographic parameters of aortic elasticity, namely aortic strain, aortic distensibility and aortic beta-index, and serum growth differentiation factor (GDF)-15 in patients with newly diagnosed essential hypertension (HT). Methods: Grade-1 HT patients (n = 50), grade-2 HT (n = 70) patients and 35 healthy controls were included. Results: GDF-15 was greater in grade-2 HT group compared with the other groups. All aortic elasticity parameters were worse in grade-2 HT group compared with the other groups. GDF-15 correlated positively with E/E ratio (the ratio of transmitral E velocity to mean diastolic mitral annular velocity) and beta-index; and aortic strain and aortic distensibility correlated negatively with serum GDF-15. beta-index, aortic diastolic diameter and diastolic blood pressure were independently associated with GDF-15. Conclusion: GDF-15 may be utilized in the prediction of increased aortic stiffness. Lay abstract: Hypertension is a leading cause of morbidity and mortality worldwide, and is closely associated with impaired arterial and aortic elasticity. Growth differentiation factor (GDF)-15 is a novel marker of cardiovascular diseases, and appeals more and more to the researchers. In the present study, we evaluated the relationship of GDF-15 with echocardiographic parameters regarding aortic stiffness, namely aortic beta-index, aortic distensibility and aortic strain in 120 newly diagnosed hypertensive patients. We found that serum GDF-15 was correlated with impaired aortic elasticity; moreover, it turned out to be a potent predictor of an increased aortic beta-index in hypertension. [GRAPHICS] |
| Anahtar Kelimeler |
| aortic elastic properties | echocardiography | GDF-15 | hypertension |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| WoS | 6 |
| Google Scholar | 16 |