| Yazarlar |
Eyüp Büyükkaya
|
|
Mehmet Fatih Karakaş
|
|
Mustafa Kurt
|
|
Perihan Bilen
|
|
Fatih Yalçın
Hatay Mustafa Kemal Üniversitesi, Türkiye |
|
Murat Çelik
|
|
Rami Helvacı
|
|
Hasan Kaya
Hatay Mustafa Kemal Üniversitesi, Türkiye |
|
Filiz Ertekin
|
Erdoğan SÖKMEN
Kırşehir Ahi Evran Üniversitesi, Türkiye |
|
Nihat Şen
|
|
Adnan Burak Akçay
Sağlık Bilimleri Üniversitesi, Türkiye |
| Özet |
| Purpose: The most important complication encountered in patients with b-thalassaemia major is degenerative fibrosis developing as a result of iron accumulation in myocardial tissue. Dysfunction pursues this accumulation. Recently, presence of fragmented QRS (fQRS) in ECG has been regarded as a predictor of myocardial fibrosis. We aimed in our study to investigate the frequency with which fQRS develops in patients with b-thalassaemia major and to disclose the correlation between fQRS frequency and Doppler-derived indices. Methods: The patients with b-thalassaemia major (n=66; mean age: 23 +/- 6 years) and healthy controls (n=30; mean age: 23 +/- 4 years) were included. fQRS pattern was described as presence of RSR' manifested as existence of additional R wave and notching in either R or S waves in ECG recordings. 2D, M-mode, conventional Doppler, tissue Doppler echocardiography parameters were assessed. Mean serum ferritin levels over past 5 years were also calculated. Results: When compared to those in control group, fQRS was more frequent in b-thalassaemia major group, indicating statistical significance (p = 0.001). While E/Em and ferritin level exhibited statistically significant increase in thalassaemia patients with fQRS (p < 0.05), the mean Em and Sm values were found to be significantly low (p < 0.05). Conclusions: fQRS was frequently observed in the patients with b-thalassaemia major, which was of statistical significance. Tissue Doppler-derived diastolic and systolic indices in thalassaemia cases with fQRS showed statistically significant impairment compared to those without fQRS. In conclusion, fQRS may represent a novel noninvasive marker for cardiac involvement in patients with b-thalassaemia major. |
| Anahtar Kelimeler |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale |
| Dergi Adı | CLINICAL AND INVESTIGATIVE MEDICINE |
| Dergi ISSN | 0147-958X |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Makale Dili | İngilizce |
| Basım Tarihi | 01-2012 |
| Cilt No | 35 |
| Sayı | 5 |
