| Yazarlar |
Osman Turak
|
|
Fırat Özcan
|
|
Ahmet İşleyen
|
|
Fatma Nurcan Başar
Türkiye |
|
Murat Gül
Aksaray Üniversitesi, Türkiye |
|
Samet Yılmaz
Pamukkale Üniversitesi, Türkiye |
Erdoğan SÖKMEN
Kırşehir Ahi Evran Üniversitesi, Türkiye |
|
Hüseyin Yüzgeçer
|
|
Gökhan Lafçı
|
|
Serkan Topaloğlu
Sağlık Bilimleri Üniversitesi, Türkiye |
|
Sinan Aydoğdu
Sağlık Bilimleri Üniversitesi, Türkiye |
| Özet |
| Background: The neutrophil-to-lymphocyte ratio is an independent predictor of worse prognosis in both infectious and cardiovascular disease. We hypothesized that an increased neutrophil-to-lymphocyte ratio at admission would predict in-hospital unfavourable outcomes in patients with infective endocarditis (IE). Methods: We retrospectively analyzed clinical, laboratory, and echocardiographic data in a total of 121 consecutive adult patients (64 men; mean age, 54.7 +/- 14.2 years) with definite IE. Results: Among all patients, the prespecified clinical outcomes were experienced in 46 patients (38%). In-hospital mortality and central nervous system (CNS) events occurred in 29 (24%) and 21 patients (17%), respectively. The neutrophil-to-lymphocyte ratio at admission was found to be significantly higher for either composite end point. On using multiple Cox regression analysis, vegetation size >= 10 mm, end-stage renal disease, Staphylococcus aureus infection, low hemoglobin level, increased C-reactive protein (CRP) level, and high neutrophil-to-lymphocyte ratio at admission emerged as independent predictors of in-hospital unfavourable outcomes. In the receiver operating characteristics (ROC) curve analysis, a neutrophil-to-lymphocyte ratio > 7.1 had 80% sensitivity and 83% specificity in predicting adverse outcomes. Conclusion: High neutrophil-to-lymphocyte ratio at admission is an independent predictor of in-hospital mortality and CNS events in patients with IE. However, prospective validation of these findings is required. |
| Anahtar Kelimeler |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale |
| Dergi Adı | CANADIAN JOURNAL OF CARDIOLOGY |
| Dergi ISSN | 0828-282X |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Makale Dili | İngilizce |
| Basım Tarihi | 12-2013 |
| Cilt No | 29 |
| Sayı | 12 |
| Sayfalar | 1672 / 1678 |
| Doi Numarası | 10.1016/j.cjca.2013.05.005 |
| Makale Linki | https://linkinghub.elsevier.com/retrieve/pii/S0828282X13003231 |
| Atıf Sayıları | |
| WoS | 61 |
