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Synthesis and antimicrobial activities of some new 1 2 4 triazolo 3 4 b 1 3 4 thiadiazoles and 1 2 4 triazolo 3 4 b 1 3 4 thiadiazines   
Yazarlar (4)
Neslihan Demirbaş
Karadeniz Teknik Üniversitesi, Türkiye
Ahmet Demirbaş
Karadeniz Teknik Üniversitesi, Türkiye
Şengül Alpay Karaoğlu
Recep Tayyip Erdoğan Üniversitesi, Türkiye
Prof. Dr. Elif SEVİM Prof. Dr. Elif SEVİM
Recep Tayyip Erdoğan Üniversitesi, Türkiye
Devamını Göster
Özet
Acetic acid hydrazides containing 1,2,4-triazol-3-one ring (4a-d) were synthesized by the reaction of compounds 2a-k with hydrazine hydrate. (5-Mercapto-1,3,4-oxadiazol-2-yl) methyl-2,4- dihydro-3H-1,2,4- triazol-3-one derivatives (5a-d) were obtained from the reaction of compounds 4a-d with carbon disulfide in the presence of KOH. The treatment of compounds 5a-d with hydrazine hydrate led to the conversion of 1,3,4- oxadiazole ring to amino- 1,2,4- triazole ring in compounds 6a-d. A second method involving the reaction of compounds 7a-d with thiocarbohydrazide also gave the same products, 6a-d. The condensation of compounds 6a-d with acetic acid produced 5-alkyl-4-amino- 2-[(6-methyl[ 1,2,4] triazolo[ 3,4- b][ 1,3,4] thiadiazol-3-yl) methyl]-2,4- dihydro-3H-1,2,4- triazol-3- ones (8a-d) while its condensation with carbon disulphide or formic acid afforded 5-alkyl-4-amino- 2-[(6-mercapto[ 1,2,4] triazolo[ 3,4b][ 1,3,4] thiadiazol-3-yl) methyl-(9a-d)and 5-alkyl-4-amino- 2-{([ 1,2,4] triazolo[ 3,4b][ 1,3,4] thiadiazol-3-ylmethyl)}-2,4- dihydro-3H- 1,2,4- triazol-3- ones ( 10a-d), respectively. On the other hand, the synthesis of 5-alkyl-4-amino- 2-[( 6-phenyl-7H-[ 1,2,4] triazolo[ 3,4b][ 1,3,4] thiadiazin-3-yl)methyl]-2,4- dihydro-3H- 1,2,4- triazol-3- ones (11a-d) were performed by the treatment of compounds 6a-d with alpha-bromo acetophenone.
Anahtar Kelimeler
Makale Türü Özgün Makale
Makale Alt Türü SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale
Dergi Adı ARKIVOC
Dergi ISSN 1551-7004 Wos Dergi Scopus Dergi
Dergi Tarandığı Indeksler SSCI
Makale Dili İngilizce
Basım Tarihi 01-2005
Cilt No 1
Sayı 1
Sayfalar 75 / 91
BM Sürdürülebilir Kalkınma Amaçları
Atıf Sayıları
Google Scholar 133

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