| Yazarlar (4) |
Arslan Kağan Arslan
Türkiye |
Dr. Öğr. Üyesi Ekin ÇELİK
Kırşehir Ahi Evran Üniversitesi, Türkiye |
|
Funda Alkan
|
|
Murat Demirbilek
Türkiye |
| Özet |
| Trauma, congenital abnormalities or cancer-induced bone defects can be treated with tissue engineering products. Graphene oxide-containing polymeric scaffolds are used as an artificial extracellular matrix, acting as an environment where cells can grow and turn into living tissues. In the presented study, primarily cytotoxicity of graphene oxide was determined depending on the concentration. According to the cytotoxicity results, two different scaffolds containing low and high concentrations of GO were prepared and usability in bone tissue engineering was examined. For this purpose, water uptake, in vitro degradation and mechanical properties of the scaffolds were determined. On the predetermined days, MC3T3 cells proliferation and ACTB, COL1A1, OCN, OPN, RUNX2 gene expression were determined. According to the results, MC3T3 cell proliferation was increased when the incubation time increased, and … |
| Anahtar Kelimeler |
| Cytotoxicity of GO | GO bone | PHBHX bone scaffolds | Osteointegration of scaffolds |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale |
| Dergi Adı | Polymer Bulletin |
| Dergi ISSN | 0170-0839 Wos Dergi Scopus Dergi |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Dergi Grubu | Q2 |
| Makale Dili | İngilizce |
| Basım Tarihi | 06-2021 |
| Cilt No | 79 |
| Sayı | 8 |
| Sayfalar | 5939 / 5954 |
| Doi Numarası | 10.1007/s00289-021-03788-6 |
| Makale Linki | http://dx.doi.org/10.1007/s00289-021-03788-6 |
| Atıf Sayıları | |
| WoS | 2 |
| Google Scholar | 2 |
