| Yazarlar (5) |
Murat Demirbilek
Ankara Hacı Bayram Veli Üniversitesi, Türkiye |
|
Nelisa Türkoğlu
Türkiye |
Dr. Öğr. Üyesi Ekin ÇELİK
Kırşehir Ahi Evran Üniversitesi, Türkiye |
|
Volkan Yalman
|
|
Funda Alkan
|
| Özet |
| Bioengineering products can help bone tissue regeneration. There is an ongoing research for more effective biomaterials in bone regeneration. Chitosan (Ch) grafted stearic acid (Ch-g-Sa) polymer was synthesized and its usability as a putty was evaluated in this study. The chemical structure of Ch-g-Sa polymer was investigated using Proton nuclear magnetic resonance (H-NMR) and Fourier-transformed infrared spectroscopy-attenuated total reflectance (FTIR-ATR). Thermal properties of Ch-g-Sa polymer were determined by thermal gravimetric analysis (TGA). Putties containing nano-hydroxyapatite were prepared and in-vitro degradation properties and viscosity of the putties were determined. The cytotoxicity, oxidation effect and osteogenic potential of the putties were investigated on MC3T3 cells while the inflammatory effect of the putties was studied on THP-1 cells. For the determination of the osteogenic effect of the putties, ALP and RUNX2 gene expression of MC3T3 cells were studied. Ch-g-Sa/HA putties are promising biomaterials for bone tissue regeneration. |
| Anahtar Kelimeler |
| Bone graft | injectable putty | chitosan-g-stearic acid putty | oxidant properties | cytokine levels |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale |
| Dergi Adı | IOS Press |
| Dergi ISSN | 0928-7329 Wos Dergi Scopus Dergi |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Makale Dili | Türkçe |
| Basım Tarihi | 05-2020 |
| Cilt No | 28 |
| Sayı | 3 |
| Sayfalar | 227 / 239 |
| Doi Numarası | 10.3233/THC-191775 |
| Makale Linki | http://dx.doi.org/10.3233/thc-191775 |
| Atıf Sayıları | |
| WoS | 3 |
| Google Scholar | 4 |
