| Yazarlar (5) |
Betül Bozdoğan Pala
Türkiye |
|
Öznur Akbal
Hacettepe Üniversitesi, Türkiye |
Dr. Öğr. Üyesi Ekin ÇELİK
Kırşehir Ahi Evran Üniversitesi, Türkiye |
|
Mustafa Türk
Kırıkkale Üniversitesi, Türkiye |
|
Emir Baki Denkbaş
Türkiye |
| Özet |
| All complex and functional structures of nature consist of simple building blocks that are thermodynamically balanced and self-assembled at the molecular level. Production of functional bio-nanomaterials with molecular self-assembly mechanisms, based on a bottom-up approach, has become increasingly important in recent years. In this study, a biodegradable and biocompatible siRNA nanocarrier system, consisting of diphenylalaninamide (FFA) based nanoparticles, was developed for silencing of HER2, a gene known to be overexpressed in breast cancer. FFA contains an amide functional group that has a dipolar nature with zero net charge. Here we report an original approach to functionalizing peptide nanoparticles based on layer-by-layer polyelectrolyte deposition (LbL PD) technique. The resulting well-defined FFA nanoparticles (FFANPs) were coated with polycationic poly-L-lysine (PLL) by cation–dipole … |
| Anahtar Kelimeler |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale |
| Dergi Adı | RSC Adv. |
| Dergi ISSN | 2046-2069 Wos Dergi Scopus Dergi |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Dergi Grubu | Q2 |
| Makale Dili | İngilizce |
| Basım Tarihi | 10-2017 |
| Cilt No | 7 |
| Sayı | 75 |
| Sayfalar | 47592 / 47601 |
| Doi Numarası | 10.1039/c7ra08460a |
| Makale Linki | http://dx.doi.org/10.1039/c7ra08460a |
| Atıf Sayıları | |
| WoS | 15 |
| Google Scholar | 20 |
