| Yazarlar (5) |
Fikret Karataş
Fırat Üniversitesi, Türkiye |
Dr. Öğr. Üyesi Ebru ÇÖTELİ
Kırşehir Ahi Evran Üniversitesi, Türkiye |
|
Süleyman Aydın
Fırat Üniversitesi, Türkiye |
|
Süleyman Servi
Fırat Üniversitesi, Türkiye |
|
Haki Kara
Sivas Cumhuriyet Üniversitesi, Türkiye |
| Özet |
| The influence of injection periods of 3-(1H-pyrrol-2-yl)-1H-indazole regarding vitamins A, E, C, selenium (Se), malondialdehyde (MDA) levels, and glutathione peroxidase (GSH-Px) activity in rats has been investigated. The substance was given by subcutaneous injection at 20 mg/kg every other day for a total of 15 injections. At the end of the treatment, Se levels in serum were determined by fluorimetry, and those of vitamins A, E, C, and malondialdehyde in serum, liver, and kidney were determined by high-performance liquid chromatography. GSH-Px activities in erythrocytes were determined spectrophotometrically. Vitamins A, E, C, and Se levels were generally lower than in the controls, while GSH-Px activity at the third injection period was maximally increased, with the activities after the other injection periods being higher than in the control group. In addition, vitamins A, E, and C levels were generally lower than the control groups, while serum, liver, and kidney MDA levels gradually increased depending on injection periods. On the other hand, GSH-Px activity was higher than in the control group. Thus, the results show that while vitamins A, E, C, and Se levels decreased, MDA levels and GSH-Px activities increased after administration of 3-(1H-pyrrol-2-yl)-1H-indazole to the rats. These findings might be related to the increased amount of free radicals caused by 3-(1H-pyrrol-2-yl)-1H-indazole injection. © 2009 Humana Press Inc. |
| Anahtar Kelimeler |
| GSH-Px | Indazole | MDA | Rat | Se | Vitamins (A, E and C) |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale |
| Dergi Adı | Biological Trace Element Research |
| Dergi ISSN | 0163-4984 |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Dergi Grubu | Q4 |
| Makale Dili | İngilizce |
| Basım Tarihi | 09-2009 |
| Cilt No | 136 |
| Sayı | 1 |
| Sayfalar | 79 / 86 |
| Doi Numarası | 10.1007/s12011-009-8517-4 |
| Makale Linki | https://doi.org/10.1007/s12011-009-8517-4 |
| Atıf Sayıları | |
| WoS | 4 |
| SCOPUS | 4 |
| Google Scholar | 5 |
