| Yazarlar (13) |
Fatih Çelik
Türkiye |
|
Ebru Çöteli
|
|
Fatih Cem Gül
Türkiye |
|
Ercan Özsoy
Türkiye |
|
Sabiha Güngör Kobat
Türkiye |
|
Zühal Karaca Karagöz
Türkiye |
|
Suna Aydın
Türkiye |
|
Kader Uğur
Erzincan Binali Yıldırım Üniversitesi, Türkiye |
|
Meltem Yardım
Fırat Üniversitesi, Türkiye |
|
İbrahim Şahin
Fırat Üniversitesi, Türkiye |
|
Mehmet Hanifi Yalçın
Türkiye |
|
Ramazan Fazıl Akkoç
Türkiye |
|
Süleyman Aydın
Türkiye |
| Özet |
| Purpose: The molecules human interleukin (IL-18), the soluble cluster of differentiation (sCD40), platelet factor 4 variant 1 (PF4V1), and neutrophil gelatinase-associated lipocalin (NGAL) are all markers of inflammation in biological systems and are linked to prognosis in several inflammatory diseases as well. Since there is no study in which the above-mentioned molecules are studied together in ocular Behçet's disease (OBD), the aim of this study is to reveal whether these molecules are activity markers in active (OABD) and inactive (OIBD) disease. Methods: 30 OABD and 30 OIBD and 30 healthy individuals were included in the study. IL-18, sCD40, PF4V1, and NGAL molecules were studied in blood samples by the ELISA method. Results: When OABD and OIBD were compared to healthy individuals, the levels of IL-18, sCD40, PF4V1, and NGAL molecules were found to be statistically significant. These values were even more significantly higher in patients with OABD. Conclusion: When ROC values of IL-18, sCD40, PF4V1, and NGAL are evaluated, it is clear that these four molecules can be used as biomarkers to aid activity and diagnosis in OBD. |
| Anahtar Kelimeler |
| Interleukin | Neutrophil gelatinase-associated lipocalin | Ocular Behçet’s disease | Platelet factor | Soluble cluster of differentiation |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale |
| Dergi Adı | International Ophthalmology |
| Dergi ISSN | 1 |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Dergi Grubu | Q4 |
| Makale Dili | İngilizce |
| Basım Tarihi | 05-2022 |
| Cilt No | 42 |
| Sayı | 11 |
| Sayfalar | 3321 / 3331 |
| Doi Numarası | 10.21203/rs.3.rs-812534/v1 |
| Makale Linki | https://doi.org/10.1007/s10792-022-02331-4 |
| Atıf Sayıları | |
| WoS | 4 |
| SCOPUS | 4 |
| Google Scholar | 5 |
