DNA repair gene XRCC1 and XRCC3 polymorphisms and their association with chronic myelogenous leukemia.
Yazarlar (6)
Prof. Dr. Serap YALÇIN AZARKAN Türkiye
Meral Sarper
Ferit Avcu
Gokhan Ozgur
Oral Nevruz
Ahmet Turker Cetin Kırşehir Ahi Evran Üniversitesi
| Makale Türü | Özgün Makale (Uluslararası alan indekslerindeki dergilerde yayınlanan tam makale) | ||
| Dergi Adı | Journal of Experimental & Integrative Medicine | ||
| Makale Dili | – | Basım Tarihi | 10-2014 |
| Cilt / Sayı / Sayfa | 4 / 4 / 241–0 | DOI | – |
| Makale Linki | https://openurl.ebsco.com/contentitem/gcd:112897358?sid=ebsco:plink:crawler-gcd&id=ebsco:gcd:112897358&crl=c&jrnl=13094572 | ||
| UAK Araştırma Alanları |
Biyokimya & Moleküler Biyoloji
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| Özet |
| Objective In this study, due to its importance in DNA repair in cancer, we searched for polymorphisms of XRCC1 and XRCC3 genes in Turkish chronic myelogenous leukemia (CML) patients. Materials and Methods In order to determine these gene polymorphisms, the polymerase chain reaction-restriction fragment length polymorphism method was applied using genomic DNA extracted from samples. Results The genotype frequencies were observed as follows: The XRCC1 Arg399Gln genotype frequencies were observed as 33.3% homozygote typical (G/G), 43.3% heterozygote (G/A) and 23.3% homozygote atypical (A/A) in the 30 samples of patients group; the genotype frequencies of XRCC3 Thr241Met were found 50% homozygote typical (C/C), 36.7% heterozygote (C/T) and 13.3% homozygote atypical (T/T) in all samples. Conclusion In this study, no statistical association was found between CML and XRCC1 … |
| Anahtar Kelimeler |
