Cytotoxic and Metastatic Effects of Anatolian Propolis and Chemotherapeutic Agents (DOX, TAM, CLB) in 2D and 3D Breast Cancer Models
Yazarlar (3)
Habibe Sema Arslan
Prof. Dr. Serap YALÇIN AZARKAN Türkiye
Gamze Turna Saltoğlu Kırşehir Ahi Evran Üniversitesi
| Makale Türü |
Özgün Makale
(Uluslararası alan indekslerindeki dergilerde yayınlanan tam makale)
|
||
| Dergi Adı | Journal of Apitherapy and Nature | ||
| Makale Dili | – | Basım Tarihi | 06-2025 |
| Cilt / Sayı / Sayfa | 8 / 1 / 103–127 | DOI | – |
| Makale Linki | https://dergipark.org.tr/en/pub/jan/issue/92504/1639903 | ||
| UAK Araştırma Alanları |
Biyokimya & Moleküler Biyoloji
|
||
| Özet |
| This study aims to comparatively investigate the cytotoxic and metastatic effects of Anatolian propolis and chemotherapeutic agents (Doxorubicin- DOX, Tamoxifen- TAM, Chlorambucil- CLB) on two-dimensional (2D) and three-dimensional (3D) breast cancer cell cultures. The triple-negative MDA-MB-231 breast cancer cell line was cultured in 2D and 3D models. Anatolian propolis was prepared using ethanol extraction and applied to the cells alone or in combination with chemotherapeutic agents (DOX, TAM, CLB) at their respective IC50 doses. Cytotoxicity was assessed using the XTT assay, while cell migration and invasion were evaluated using wound healing and invasion assays. Propolis, when combined with chemotherapeutic agents, significantly inhibited cell proliferation and migration (p |
| Anahtar Kelimeler |
