Comparative cytotoxic and molecular effects of deltamethrin and acetamiprid in normal and cancerous human liver cell lines
Yazarlar (3)
Cansu Aydın
Selin Özkan-Kotiloğlu
Prof. Dr. Serap YALÇIN AZARKAN Kırşehir Ahi Evran Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (Uluslararası alan indekslerindeki dergilerde yayınlanan tam makale) | ||
| Dergi Adı | Cell Biochemistry and Biophysics | ||
| Makale Dili | – | Basım Tarihi | 02-2026 |
| Cilt / Sayı / Sayfa | 0 / 0 / 1–15 | DOI | 10.1007/s12013-026-02006-2 |
| Makale Linki | https://link.springer.com/article/10.1007/s12013-026-02006-2 | ||
| UAK Araştırma Alanları |
Biyokimya & Moleküler Biyoloji
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| Özet |
| Deltamethrin (a pyrethroid) and acetamiprid (a neonicotinoid) are widely used insecticides that have raised increasing concerns due to their potential toxicity. This study aimed to investigate their cytotoxic, morphological and molecular effects on normal (Thle-2) and cancerous (HepG2) human liver cell lines, as well as their interactions with key antioxidant-related enzymes. IC50 values were determined using XTT assay following 24- and 48 h exposures to each compound individually and in combination. Cell motility was evaluated using wound healing assays, while oxidative stress-related gene expressions (CAT, SOD1, GSTK1) were analysed by qRT-PCR.In Thle-2 cells, CAT and GSTK1 expression significantly decreased after acetamiprid exposure (p < 0.05). In HepG2 cells, GSTK1 expression decreased with individual treatments but increased significantly under combined exposure compared to … |
| Anahtar Kelimeler |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Google Scholar | 1 |