New sulfonylhydrazones containing methane sulfonic acid hydrazıde havıng human anticarbonic anhydrase and antimicrobıal activıty: synthesis, spectroscopic characterization …
Yazarlar (8)
Ayla Balaban Gündüzalp
Demet Uzun
Olkar Abdulmajed
Kerem Kaya
Ali Öztürk
Ebru Erdoğdu
Ümmühan Özdemir Özmen
| Makale Türü |
Özgün Makale
(Uluslararası alan indekslerindeki dergilerde yayınlanan tam makale)
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| Dergi Adı | Macedonian Journal of Chemistry and Chemical Engineering | ||
| Makale Dili | – | Basım Tarihi | 12-2021 |
| Cilt / Sayı / Sayfa | 40 / 2 / 181–196 | DOI | – |
| Makale Linki | https://mjcce.org.mk/index.php/MJCCE/article/view/2416 | ||
| UAK Araştırma Alanları |
Anorganik Kimya
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| Özet |
| In this work, new sulfonylhydrazones nomenclatured as 3, 5-ditertbutylsalicylaldehyde methanesulfonylhydrazone (II), 3-tertbutylsalicylaldehyde methanesulfonylhydrazone (III), and 5-bromosalicylaldehyde methanesulfonylhydrazone (IV) were synthesized by the reaction of methanesulfonicacidhydrazide (I) with 3, 5-ditertbutylsalicylaldehyde, 3-tertbutylsalicyl aldehyde, and 5-bromosalicylaldehyde. The structures of the aromatic sulfonylhydrazones were determined by using elemental analysis, UV-Vis, FT-IR, 1 H-NMR, and 13 C-NMR methods. The structure of IV was also supported with the X-ray diffraction method. Sulfonamides were generally investigated for their inhibitory effects on human carbonic anhydrase isoenzymes (hCAs). Synthesized alkylsulfonylhydrazones have a sulfonamide group, which is the most important pharmacophore for the carbonic anhydrase (CA) inhibition efficiency like the reference agent acetazolamide (AAZ). The enzyme inhibition trends of alkylsulfonylhydrazones on the hCA I isoenzyme were qualitatively investigated by cyclic voltammetry (CV) and differantial pulse voltammetry (DPV). Also, the inhibition activities of sulfonylhydrazones were determined by using UV-Vis spectrophotometry, and their inhibition parameters, such as K m, IC 50, and K i, were calculated. Among the tested compounds, IV was found to be the most active compound on the hCA I isoenzyme with an IC 50 value of 4.86× 10–6 M, whereas II and III were found to be the least potent compounds on hCA I with an IC 50 value of 3.96× 10–4 M and 5.58× 10–5 M, respectively. |
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