Evaluation of cytotoxic and apoptotic effects of the extracts and phenolic compounds of Astragalus globosus Vahl and Astragalus breviflorus DC
Yazarlar (7)
Benan Kalaycı
Nihal Şimşek Özek
Ferhunde Aysin
Hilal Özbek
Cavit Kazaz
Prof. Dr. Mehmet Mustafa ÖNAL Türkiye
Prof. Dr. Zühal Güvenalp Kırşehir Ahi Evran Üniversitesi
| Makale Türü | Özgün Makale (Uluslararası alan indekslerindeki dergilerde yayınlanan tam makale) | ||
| Dergi Adı | Saudi Pharmaceutical Journal | ||
| Makale Dili | – | Basım Tarihi | 08-2023 |
| Cilt / Sayı / Sayfa | 31 / 8 / 101682–0 | DOI | – |
| Makale Linki | https://www.sciencedirect.com/science/article/pii/S1319016423001755 | ||
| UAK Araştırma Alanları |
Betonarme Yapılar
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| Özet |
| Astragalus L. is a genus member of the Fabaceae family, representing about 3,000 species all over the world and 380 species in Turkey. Astragalus species have been used in traditional medicine for many years. Astragalus globosus Vahl, known as “top geven”, is a dwarf, scapose, perennial herb, Astragalus breviflorus DC., known as “yünlü geven”, is an extremely spiny dwarf shrub. These endemic species grow in the Turkish cities of Erzurum, Kars, and Van. This is the first phytochemical and cytotoxic investigation of Astragalus globosus Vahl and Astragalus breviflorus DC. The main extracts and sub-fractions from the plants were evaluated for in vitro cytotoxic and apoptotic activities. The IC50 values of dichloromethane, n-butanol, and water extracts of the aerial parts of A. globosus against the MCF-7 cell line were determined as 28.39, 868.60, and 1753.00 µg/mL. The values for the MDA-MB-231 cell line were … |
| Anahtar Kelimeler |
