FRUITFUL REMEDIES: ANALYZING THERAPEUTIC POTENTIALS IN ESSENTIAL AND FATTY OILS, AND AQUEOUS EXTRACTS FROM PRUNUS CERASIFERA, MALUS SYLVESTRIS, AND CORNUS MAS USING LC-MS AND GC-MS
Yazarlar (10)
Bilge Aydın
Hafize Yuca
Gözde Öztürk
Enes Tekman
Songül Karakaya
Gamze Göger
Prof. Dr. Mehmet Mustafa ÖNAL Türkiye
Betül Demirci
Zuhal Güvenalp
Oksana Sytar
Kırşehir Ahi Evran Üniversitesi
Kırşehir Ahi Evran Üniversitesi
| Makale Türü | Özgün Makale (Uluslararası alan indekslerindeki dergilerde yayınlanan tam makale) | ||
| Dergi Adı | Journal of Faculty of Pharmacy of Ankara University | ||
| Makale Dili | – | Basım Tarihi | 05-2025 |
| Cilt / Sayı / Sayfa | 49 / 2 / 402–424 | DOI | – |
| Makale Linki | https://dergipark.org.tr/en/pub/jfpanu/article/1562768 | ||
| UAK Araştırma Alanları |
Betonarme Yapılar
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| Özet |
| Objective The chemical composition and bioactive properties of essential oils, fatty oils and aqueous extracts of Prunus cerasifera, Malus sylvestris and Cornus mas were investigated. Material and Method Antidiabetic, antimicrobial, anticholinesterase and antioxidant activities of P. cerasifera, M. sylvestris and C. mas were reported. The quantitative determination of some secondary metabolites was also analysed by LC-MS/MS. The chemical composition of the essential oils was also investigated by GC-MS. Result and Discussion Fatty oils’ major compounds were oleic acid (77.1%) in P. cerasifera, palmitic acid (32.5%) in M. sylvestris fruits, and linoleic acid (43.2%) in C. mas seeds. Benzaldehyde (70.1%), nonacosane (30.4%), (E,E)-2,4-Decadienal (43.3%) were found as major compounds of P. cerasifera, M. sylvestris fruits, and C. mas seed essential oils, respectively. Quinic acid was predominant compound in all extracts, ranging from 11262.2996 to 18179.6260 ng/ml. C. mas fatty oil was showed antimicrobial activity against Candida albicans and C. parapsilosis with MIC =625-1250 µg/ml. P. cerasifera, C. mas, and M. sylvestris hold potential as α-glucosidase inhibitors, with varying degrees of potency. IC50 values further underscore effectiveness of aqueous extracts, especially in cases of C. mas and M. sylvestris with <10 and 399 µg/ml. |
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