Antimicrobial and anticancer evaluation of Juniperus chinensis seed oil with molecular docking of α-cedrol-AKT1
Yazarlar (3)
Muruvvet Kurt
Safiye Elif Korcan
Prof. Dr. Serap YALÇIN AZARKAN Kırşehir Ahi Evran Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | ACTA CHIMICA SLOVENICA (Q3) | ||
| Dergi ISSN | 1318-0207 Wos Dergi Scopus Dergi | ||
| Makale Dili | İngilizce | Basım Tarihi | 01-2026 |
| Cilt / Sayı / Sayfa | 73 / 1 / 223–235 | DOI | 10.17344/acsi.2025.9517 |
| Makale Linki | https://scholar.google.com/scholar?cluster=7186256192795624273&hl=en&oi=scholarr | ||
| UAK Araştırma Alanları |
Sağlık Bilimleri
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| Özet |
| In this study, the essential oil of Juniperus chinensis L. seeds was analyzed by GC-MS, identifying 25 comprising comprising 99.78% of the oil. alpha-Pinene (79.63 +/- 0.45%) was the major component, followed by (3-myrcene, (3-pinene, and DL-limonene. The oil exhibited antimicrobial activity with inhibition zones of 11 mm (S. aureus), 6 mm (E. coli), and 4 mm (S. mutans). Antifungal effects were noted against Fusarium solani and Aspergillus niger. Cytotoxicity assays revealed selective effects on MDA-MB-231 breast cancer cells (IC50: 38 & micro;g/mL), with no toxicity to MCF-10A normal cells. Molecular docking demonstrated strong binding affinity of alpha-cedrol to AKT-1 protein (-7.5 kcal/mol), supported by RMSD stability analysis and hydrogen bonding. ADME profiling confirmed favorable drug-likeness of alpha-cedrol. These results suggest that J. chinensis L. seed essential oil, particularly as a complex … |
| Anahtar Kelimeler |
| Juniperus chinensis L. | seed oil | GC-MS | alpha-cedrol | antimicrobial efficacy | molecular docking | anticancer potential |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 1 |
| Google Scholar | 1 |