Evaluation of the anticancer effects of ellagic acid and cisplatin in cisplatin-sensitive and -resistant MDA-MB-231 breast cancer cells
Yazarlar (4)
Dr. Öğr. Üyesi Gamze TURNA SALTOĞLU Kırşehir Ahi Evran Üniversitesi, Türkiye
Prof. Dr. Serap YALÇIN AZARKAN Kırşehir Ahi Evran Üniversitesi, Türkiye
Gulistan Sanem Saribas
Seda Yalcinkaya
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | MEDICAL ONCOLOGY (Q2) | ||
| Dergi ISSN | 1357-0560 Wos Dergi Scopus Dergi | ||
| Makale Dili | İngilizce | Basım Tarihi | 03-2026 |
| Cilt / Sayı / Sayfa | 43 / 4 / 162–0 | DOI | 10.1007/s12032-026-03270-1 |
| Makale Linki | https://link.springer.com/article/10.1007/s12032-026-03270-1 | ||
| UAK Araştırma Alanları |
Sağlık Bilimleri
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| Özet |
| Ellagic acid (EA) is a natural polyphenol noted for its antiproliferative and pro-apoptotic effects. This study investigates the impact of EA, alone or combined with cisplatin (CIS), on the expression of angiogenesis, apoptosis, metastasis, and chemoresistance-related genes and proteins in cisplatin-sensitive and -resistant MDA-MB-231 breast cancer cells. Cell viability was evaluated by cytotoxicity assay, while gene and protein expression levels were analyzed via qPCR and immunocytochemistry. Molecular docking was used to assess EA’s binding affinity to target proteins. The IC₅₀ values of EA and CIS were 29 µM and 38.2 µM in cisplatin-sensitive MDA-MB-231 cells, and 49.5 µM and 80.2 µM in cisplatin-resistant cells, respectively. In both cell types, EA significantly decreased the expression of the ABCB1 and VEGF genes, especially at 24 and 48 h. EA alone and combined with CIS suppressed MMP2 and MMP9 … |
| Anahtar Kelimeler |
| Ellagic acid | Cisplatin | Breast cancer | Chemoresistance |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Google Scholar | 1 |