Potent α-glucosidase and tyrosinase inhibition by thiophene-based Schiff bases: Experimental and computational evaluation
Yazarlar (5)
Öğr. Gör. Emel Ekinci Çankırı Karatekin Üniversitesi, Türkiye
Dr. Öğr. Üyesi Kübra ÖZTÜRK Kırşehir Ahi Evran Üniversitesi, Türkiye
Doç. Dr. Özlem GÜNDOĞDU AYTAÇ Kırşehir Ahi Evran Üniversitesi, Türkiye
Doç. Dr. Sertan AYTAÇ Kırşehir Ahi Evran Üniversitesi, Türkiye
Prof. Dr. Harun ÇİFTÇİ Kırşehir Ahi Evran Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | LETTERS IN DRUG DESIGN & DISCOVERY (Q4) | ||
| Dergi ISSN | 1570-1808 Dergi Bilgileri (2026) | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 01-2026 |
| Cilt / Sayı / Sayfa | 23 / 1 / – | DOI | 10.1016/j.lddd.2026.100366 |
| Makale Linki | https://doi.org/10.1016/j.lddd.2026.100366 | ||
| UAK Araştırma Alanları |
Organik Kimya
Biyokimya
Teorik Kimya
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| Özet |
| In this study, novel thiophene-based Schiff base derivatives were synthesized, and their structures were comprehensively analyzed. The inhibitory potentials of these compounds on α-glucosidase and tyrosinase enzymes were systematically evaluated. Among the thiophene-based Schiff bases, compound 8 exhibited moderate inhibitory activity against both α-glucosidase and tyrosinase, with IC50 values of 173.29 and 69.32 µM for each, compared to the positive controls acarbose and kojic acid, respectively. The DFT approach was used to analyze the reactivity and molecular electrostatic potential maps of the compounds, and molecular docking studies for the most active compounds 4, 6, and 8 were conducted on both the fungal tyrosinase and Saccharomyces cerevisiae protein models. Furthermore, ADME (Absorption, Distribution, Metabolism, and Excretion) analyses were performed to evaluate their … |
| Anahtar Kelimeler |
| Thiophene | Schiff base | Diabetes | Hyperpigmentation | Enzyme inhibition | Molecular docking | ADME |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 1 |
| Google Scholar | 1 |