Cytotoxic and Oxidative Stress–Related Effects of N2O2-Type Ni(II)-Thiosemicarbazone Complexes: Experimental and Computational Studies
Yazarlar (6)
Adem Güner Sinop Üniversitesi, Türkiye
Qumars Poladian
Kabul University, Afganistan
Kabul University, Afganistan
Prof. Dr. Tuncay KARAKURT Kırşehir Ahi Evran Üniversitesi, Türkiye
Doç. Dr. Berat İlhan Ceylan Istanbul Üniversitesi, Türkiye
Onur Şahin Sinop Üniversitesi, Türkiye
Öğr. Gör. Yasemin Kurt Istanbul Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Chemico Biological Interactions (Q1) | ||
| Dergi ISSN | 0009-2797 Dergi Bilgileri (2026) | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | Türkçe | Basım Tarihi | 02-2026 |
| Cilt / Sayı / Sayfa | 430 / 1 / – | DOI | 10.1016/j.cbi.2026.111995 |
| Makale Linki | https://doi.org/10.1016/j.cbi.2026.111995 | ||
| UAK Araştırma Alanları |
Yoğun Madde Fiziği
Atom, Molekül ve Lazer Fiziği
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| Özet |
| New thiosemicarbazone-based Ni(II) complexes, [Ni(L1–3)] (1–3), were synthesized, structurally characterized, and evaluated for their cytotoxic potential in a panel of human cervical (HeLa), lung (A549), breast (MDA-MB-231), and pancreatic (PANC-1) cancer cells, along with a non-cancerous human embryonic kidney (HEK-293) cell line. The complexes exhibited selective cytotoxic effects, with HeLa cells showing the highest sensitivity. Among them, complex 2 demonstrated the most pronounced antiproliferative activity and selectivity compared to complexes 1 and 3. Cellular studies in HeLa cells revealed increased oxidative stress markers, mitochondrial dysfunction, and apoptosis-related alterations accompanying the observed cytotoxicity. Chemical antioxidant assays indicated higher radical-scavenging activity for the free ligand, whereas complex 2 displayed the highest TEAC value among the metal … |
| Anahtar Kelimeler |
| Antioxidant | Citotoxicity | Molecular docking | Nickel | Propiophenone | Thiosemicarbazone |
Science Direct
Cytotoxic and Oxidative Stress–Related Effects of N2O2-Type Ni(II)-Thiosemicarbazone Complexes: Experimental and Computational Studies
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| Atıf Sayıları | |
| Web of Science | 1 |
| Google Scholar | 1 |