Evaluating The Cytotoxic and Metastatic Actions of Cannabinol on HCT-116 Colon Cancer Cells
Yazarlar (4)
Dr. Öğr. Üyesi Gamze TURNA SALTOĞLU Kırşehir Ahi Evran Üniversitesi, Türkiye
Prof. Dr. Serap YALÇIN AZARKAN Kırşehir Ahi Evran Üniversitesi, Türkiye
Bayram Furkan Çoşkun
Habibe Sema Arslan
| Makale Türü |
Özgün Makale
(Ulusal alan endekslerinde (TR Dizin, ULAKBİM) yayınlanan tam makale)
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| Dergi Adı | Osmangazi Journal of Med | ||
| Dergi ISSN | 1305-4953 | ||
| Dergi Tarandığı Indeksler | TR DİZİN | ||
| Makale Dili | Türkçe | Basım Tarihi | 01-2025 |
| Cilt / Sayı / Sayfa | 47 / 4 / 593–599 | DOI | 10.20515/otd.1651353 |
| Makale Linki | https://dergipark.org.tr/tr/pub/otd | ||
| UAK Araştırma Alanları |
Tıbbi Farmakoloji
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| Özet |
| It aims to evaluate the cytotoxic and metastatic effects of cannabinol (CBN) on HCT-116 colon cancer cells. Colorectal cancer is one of the leading causes of cancer-related mortality worldwide, with high recurrence and metastasis rates despite current treatment approaches. In recent years, the antitumor potential of cannabinoids has gained attention; however, the specific effects of CBN remain largely unexplored. HCT-116 colon cancer cells were cultured under laboratory conditions and treated with CBN. Cell viability was assessed using the XTT cytotoxicity assay, while cell migration and invasion capabilities were analyzed through the wound healing assay and invasion assay, respectively. The acquired data were quantified using ImageJ software and statistically evaluated with GraphPad Prism 8. The IC₅₀ value of CBN was determined to be 69.14 μM, and CBN treatment was found to significantly reduce cell viability (p<0.05). Wound healing assay results demonstrated that CBN treatment markedly inhibited cell migration (p<0.05). Invasion analyses revealed that CBN significantly reduced invasiveness and provided a notable inhibition compared to the control group (p<0.05). This provides significant evidence that CBN suppresses metastatic processes in HCT-116 cells. This study supports the potential of CBN as an inhibitor of cytotoxic and metastatic activity in colon cancer cells. The findings indicate that CBN reduces cell proliferation, migration, and invasion, suggesting its potential as a therapeutic agent in colorectal cancer treatment. However, further research is needed to elucidate the underlying molecular mechanisms and validate … |
| Anahtar Kelimeler |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Google Scholar | 1 |