| Yazarlar (5) |
Oya Korkmaz
Malatya Turgut Özal Üniversitesi, Türkiye |
Dr. Öğr. Üyesi Sadık KÜÇÜKGÜNAY
Kırşehir Ahi Evran Üniversitesi, Türkiye |
|
Ali Erdem Öztürk
Erciyes Üniversi, Türkiye |
|
Halime Tozak Yıldız
Kırşehir Ahi Evran Üniversitesi, Türkiye |
|
Mustafa Numan Bucak
Selçuk, Türkiye |
| Özet |
| Paclitaxel (PTS) is a widely used chemotherapy drug for various types of cancer, but it often causes significant toxicity in multiple organ systems. The aim of this study was to investigate the deleterious effects of PTS on liver, kidney and heart in an experimental animal model. Male Balb/c mice aged 8-10 weeks were included in the study. Mice were divided into two groups as control (n: 5) and PTS (n: 5). On the 1st, 3rd and 5th days, saline was administered intraperitoneally to control group mice and 2 mg/kg PTS to PTS group mice. Animals were sacrificed on day 7 and liver, kidney and heart tissues were collected and histopathological examinations (Hematoxylin Eosin and Masson Trichrome staining) were performed. While the liver tissue of the control group showed a normal histological appearance, marked damage such as apoptotic cell increase, congestion, sinusoidal dilatation, epithelial vacuolisation, central vein dilatation and mononuclear cell infiltration were observed in the PTS group (p< 0.001). In the PTS group, atrophy of tubules and renal corpuscles, loss of brushy edge, tubular dilatation, interstitial oedema and vascular congestion were observed (p< 0.001). Myocardial necrosis, abnormal arrangement of fibres, oedema and increased mononuclear cell infiltration were observed in cardiac tissue in the PTS group. Our findings indicate that PTS has a damaging potential on liver, kidney and heart. |
| Anahtar Kelimeler |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | Uluslararası alan indekslerindeki dergilerde yayınlanan tam makale |
| Dergi Adı | Kocatepe Veterinary Journal |
| Dergi Tarandığı Indeksler | |
| Makale Dili | Türkçe |
| Basım Tarihi | 12-2025 |
| Cilt No | 18 |
| Sayı | 4 |
| Sayfalar | 393 / 404 |
