Defective Treg generation and increased type 3 immune response in leukocyte adhesion deficiency 1
Yazarlar (25)
Dr. Öğr. Üyesi Şerife ERDEM Türkiye
Zehra Şule Haskoloğlu Türkiye
Yeşim Haliloglu
Huriye Çelikzencir
Elif Arık
Türkiye
Türkiye
Özlem Keskin Türkiye
Sevgi Bilgiç Ertan
Esra Yücel Türkiye
Halit Canatan Türkiye
Hüseyin Avcılar Türkiye
Ebru Yılmaz Türkiye
Alper Özcan Türkiye
Ekrem Ünal Türkiye
Musa Karakükcü Erciyes Üniversitesi, Türkiye
Mehmet Halil Çeliksoy
Türkiye
Türkiye
Şebnem Sara Kılıç
Ayça Demir Türkiye
Ferah Genel
Türkiye
Türkiye
Nesrin Gülez
Türkiye
Türkiye
Mustafa Yavuz Köker Türkiye
İsmail Reisli Türkiye
Sevgi Keleş Türkiye
Esin Figen Doğu Türkiye
Kamile Aydan İkincioğulları Türkiye
Ahmet Eken Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Elsevier BV (Q1) | ||
| Dergi ISSN | 1521-6616 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | Türkçe | Basım Tarihi | 08-2023 |
| Cilt / Sayı / Sayfa | 253 / 0 / – | DOI | 10.1016/j.clim.2023.109691 |
| Makale Linki | http://dx.doi.org/10.1016/j.clim.2023.109691 | ||
| Özet |
| In 15 Turkish LAD-1 patients and controls, we assessed the impact of pathogenic ITGB2 mutations on Th17/Treg differentiation and functions, and innate lymphoid cell (ILC) subsets. The percentage of peripheral blood Treg cells, in vitro-generated induced Tregs differentiated from naive CD4 T cells were decreased despite the elevated absolute counts of CD4 cells in LAD-1 patients. Serum IL-23 levels were elevated in LAD-1 patients. Post-curdlan stimulation, LAD-1 patient-derived PBMCs produced more IL-17A. Additionally, the percentages of CD18-deficient Th17 cells expanded from total or naïve CD4 T cells were higher. The blood ILC3 subset was significantly elevated in LAD-1. Finally, LAD-1 PBMCs showed defects in trans-well migration and proliferation and were more resistant to apoptosis. Defects in de novo generation of Tregs from CD18-deficient naïve T cells and elevated Th17s, and ILC3s in LAD-1 patients' peripheral blood suggest a type 3-skewed immunity and may contribute to LAD-1-associated autoimmune symptoms. |
| Anahtar Kelimeler |
| Leukocyte adhesion deficiency | LAD-1 | Th17 | ILC | Treg |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 5 |