| Yazarlar (2) |
Dr. Öğr. Üyesi Kübra Tuğçe KALKAN
Kırşehir Ahi Evran Üniversitesi, Türkiye |
Dr. Öğr. Üyesi Ferhat PEKTAŞ
Kırşehir Ahi Evran Üniversitesi, Türkiye |
| Özet |
| Monosodium glutamate (MSG), a widely used flavor enhancer, has been associated with hepatotoxicity through mechanisms involving oxidative stress, inflammatory activation, and disruption of autophagy. L‐Carnitine, recognized for its antioxidant and anti‐inflammatory effects, has been proposed as a potential therapeutic agent against liver injury. This study aimed to evaluate the hepatotoxic effects of monosodium glutamate (MSG) and the therapeutic potential of L‐carnitine in mitigating MSG‐induced liver injury, with emphasis on autophagy‐related pathways. Forty male offspring obtained from 12 pregnant Wistar albino rats were divided into five groups (n = 8 per group): control, sham, MSG, L‐carnitine, and MSG + L‐carnitine. Neonatal rats received MSG (4 g/kg, s.c.) on postnatal days 2, 4, 6, 8, and 10, whereas L‐carnitine (200 mg/kg, i.p.) was administered between postnatal days 60–81. Biochemical … |
| Anahtar Kelimeler |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale |
| Dergi Adı | Journal of Applied Toxicology |
| Dergi ISSN | 0260-437X Wos Dergi Scopus Dergi |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Dergi Grubu | Q2 |
| Makale Dili | İngilizce |
| Basım Tarihi | 12-2025 |
| DOI Numarası | 10.1002/jat.70045 |
| Makale Linki | https://doi.org/10.1002/jat.70045 |
| Atıf Sayıları |
