Protective effects of rutin against docetaxel-induced testicular damage in rats: Effects on antioxidant defence, apoptosis and autophagy
Yazarlar (7)
Dr. Öğr. Üyesi Sadık KÜÇÜKGÜNAY Kırşehir Ahi Evran Üniversitesi, Türkiye
Doç. Dr. Halime TOZAK YILDIZ Kırşehir Ahi Evran Üniversitesi, Türkiye
Oya Korkmaz Malatya Turgut Ozal University, Türkiye
Prof. Dr. Memiş BOLACALI Kırşehir Ahi Evran Üniversitesi, Türkiye
Mustafa Numan Bucak Selçuk Üniversitesi, Türkiye
Hasan Ali Çay Burdur Mehmet Akif Ersoy Üniversitesi, Türkiye
Şöhret Güler Burdur Mehmet Akif Ersoy Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Reproductive Toxicology (Q2) | ||
| Dergi ISSN | 0890-6238 Dergi Bilgileri (2026) | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | Türkçe | Basım Tarihi | 01-2026 |
| Cilt / Sayı / Sayfa | 139 / 1 / 1–13 | DOI | 10.1016/j.reprotox.2025.109110 |
| Makale Linki | https://doi.org/10.1016/j.reprotox.2025.109110 | ||
| UAK Araştırma Alanları |
Ziraat, Orman ve Su Ürünleri
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| Özet |
| Docetaxel (DTX), a widely used chemotherapeutic agent, is known for its effectiveness in cancer treatment but also for its toxic effects on healthy tissues, particularly the male reproductive system. This study aimed to investigate the protective role of rutin, a natural flavonoid with known antioxidant and anti-apoptotic properties, against DTX-induced testicular damage in rats.Thirty-six adult male Wistar rats were randomly divided into six groups: Control, Rutin 50 mg/kg (R50), Rutin 100 mg/kg (R100), DTX, DTX+R50, and DTX+R100. A single dose of DTX (30 mg/kg, i.p.) was administered, while rutin was given orally for 7 days. On day eight, all animals were sacrificed. Sperm parameters (concentration, motility, morphology, chromatin integrity), serum testosterone and inhibin B levels, and testicular MDA and SOD levels were assessed. Histological evaluations were conducted using hematoxylin-eosin staining … |
| Anahtar Kelimeler |
| Apoptosis | Autophagy | Docetaxel | Oxidative stress | Rutin | Testicular toxicity |
Science Direct
Protective effects of rutin against docetaxel-induced testicular damage in rats: Effects on antioxidant defence, apoptosis and autophagy
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| Atıf Sayıları | |
| Google Scholar | 1 |