| Yazarlar (4) |
Dr. Öğr. Üyesi Halime TOZAK YILDIZ
Kırşehir Ahi Evran Üniversitesi, Türkiye |
Ahmet Türk
Adıyaman Üniversitesi, Türkiye |
Dr. Öğr. Üyesi Ertan KATIRCI
Kırşehir Ahi Evran Üniversitesi, Türkiye |
Dr. Öğr. Üyesi Kübra Tuğçe KALKAN
Kırşehir Ahi Evran Üniversitesi, Türkiye |
| Özet |
| BackgroundInsulin resistance (IR) is a central pathological mechanism underlying metabolic syndrome and associated disorders, including type 2 diabetes and non-alcoholic fatty liver disease. This study investigated the therapeutic effects of darbepoetin alfa (DA), an erythropoietin analogue, in a dexamethasone (Dexa)-induced IR model, focusing on its impact on metabolic regulation (apelin) and inflammatory pathways (galectin-3) in liver tissue.Materials and methodsThirty-two male Wistar rats were divided into four groups (n = 8/group): (saline 1 ml/kg/day intraperitoneal [ip] for 5 days), IR (Dexa 1 mg/kg/day ip for 5 days), DA (single 5 µg/kg ip dose on day 6), and IR + DA (Dexa followed by DA). Body weight, fasting glucose, insulin levels, and HOMA-IR were assessed. Liver function was evaluated via AST/ALT levels, while histopathological changes (hydropic degeneration, necrosis, fibrosis via Masson’s … |
| Anahtar Kelimeler |
| Makale Türü |
Özgün Makale
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| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale |
| Dergi Adı | BMC Pharmacology and Toxicology |
| Dergi ISSN | 2050-6511 Wos Dergi Scopus Dergi |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Dergi Grubu | Q2 |
| Makale Dili | Türkçe |
| Basım Tarihi | 10-2025 |
| Cilt No | 26 |
| Sayı | 173 |
| Sayfalar | 4 / 11 |
| Doi Numarası | 10.1186/s40360-025-01014-x |
| Makale Linki | https://doi.org/10.1186/s40360-025-01014-x |
| Atıf Sayıları |
