Hepatic modulation of apelin and galectin-3 by darbepoetin-alpha in Dexamethasone induced insulin-resistant rats
Yazarlar (4)
Dr. Öğr. Üyesi Halime TOZAK YILDIZ Kırşehir Ahi Evran Üniversitesi, Türkiye
Ahmet Türk Adıyaman Üniversitesi, Türkiye
Dr. Öğr. Üyesi Ertan KATIRCI Kırşehir Ahi Evran Üniversitesi, Türkiye
Dr. Öğr. Üyesi Kübra Tuğçe KALKAN Kırşehir Ahi Evran Üniversitesi, Türkiye
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Özgün Makale
(SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale)
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| Dergi Adı | BMC Pharmacology and Toxicology (Q2) | ||
| Dergi ISSN | 2050-6511 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | Türkçe | Basım Tarihi | 10-2025 |
| Cilt / Sayı / Sayfa | 26 / 173 / 4–11 | DOI | 10.1186/s40360-025-01014-x |
| Makale Linki | https://doi.org/10.1186/s40360-025-01014-x | ||
| Özet |
| BackgroundInsulin resistance (IR) is a central pathological mechanism underlying metabolic syndrome and associated disorders, including type 2 diabetes and non-alcoholic fatty liver disease. This study investigated the therapeutic effects of darbepoetin alfa (DA), an erythropoietin analogue, in a dexamethasone (Dexa)-induced IR model, focusing on its impact on metabolic regulation (apelin) and inflammatory pathways (galectin-3) in liver tissue.Materials and methodsThirty-two male Wistar rats were divided into four groups (n = 8/group): (saline 1 ml/kg/day intraperitoneal [ip] for 5 days), IR (Dexa 1 mg/kg/day ip for 5 days), DA (single 5 µg/kg ip dose on day 6), and IR + DA (Dexa followed by DA). Body weight, fasting glucose, insulin levels, and HOMA-IR were assessed. Liver function was evaluated via AST/ALT levels, while histopathological changes (hydropic degeneration, necrosis, fibrosis via Masson’s … |
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BM Sürdürülebilir Kalkınma Amaçları
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| Google Scholar | 2 |