| Yazarlar (11) |
Tuğba Tezcan
|
Doç. Dr. Selin ÖZKAN KOTİLOĞLU
Kırşehir Ahi Evran Üniversitesi, Türkiye |
|
Mukaddes Asena Yıldırım
|
|
Mustafa Danışman
|
|
H. Ceren Bozmaoğlu
|
|
Kenan Can Tok
Ankara Üniversitesi, Türkiye |
|
İrem Kar
Türkiye |
|
Mehmet Gümüştaş
Ankara Üniversitesi, Türkiye |
|
İnci İlhan
Ankara Üniversitesi, Türkiye |
|
Halit Sinan Süzen
Ankara Üniversitesi, Türkiye |
|
Dilek Akyüzlü
Ankara Üniversitesi, Türkiye |
| Özet |
| This study investigated whether hsa-miR-29a-3p expression affects diazepam (DZP) metabolism by modulating CYP2C19 gene expression in patients with alcohol withdrawal syndrome (AWS). Blood samples were obtained from 75 male AWS patients. hsa-miR-29a-3p expression was quantified using qRT-PCR, and plasma DZP and its active metabolite nordiazepam (NDZP) levels were measured via HPLC. No significant correlations were found between hsa-miR-29a-3p expression and DZP dose, plasma DZP/NDZP levels, dose-adjusted or weight-adjusted concentrations, or the metabolite-to-parent drug ratio. However, hsa-miR-29a-3p expression levels were significantly higher in patients exhibiting confusion (p = 0.016) and excessive fatigue (p = 0.039). Although hsa-miR-29a-3p did not appear to influence diazepam biotransformation directly, this study is the first to report a potential link between elevated hsa-miR-29a-3p expression and neuropsychiatric symptoms in AWS, suggesting a possible role of this microRNA in the clinical presentation of alcohol withdrawal. |
| Anahtar Kelimeler |
| Alcohol withdrawal syndrome | CYP2C19 | Diazepam | Pharmacoepigenetics | hsa-miR-29a-3p |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale |
| Dergi Adı | Environmental Toxicology and Pharmacology |
| Dergi ISSN | 1382-6689 Wos Dergi Scopus Dergi |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Dergi Grubu | Q1 |
| Makale Dili | Türkçe |
| Basım Tarihi | 12-2025 |
| Cilt No | 120 |
| Sayfalar | 104861 / 0 |
| Doi Numarası | 10.1016/j.etap.2025.104861 |
| Makale Linki | https://doi.org/10.1016/j.etap.2025.104861 |
| Atıf Sayıları |
