| Yazarlar (6) |
Özlem Gündoğdu Aytaç
Kırşehir Ahi Evran Üniversitesi, Türkiye |
|
Hilal Başak Gündoğdu
Atatürk Üniversitesi, Türkiye |
|
Sertan Aytaç
Kırşehir Ahi Evran Üniversitesi, Türkiye |
|
Zeynebe Bingöl
Tokat Gaziosmanpaşa Üniversitesi, Türkiye |
|
İlhami Gülçin
Atatürk Üniversitesi, Türkiye |
|
Yunus Kara
Atatürk Üniversitesi, Türkiye |
| Özet |
| It is known that compounds containing isoxazole units exhibit a high potential for biological activity due to the isoxazole ring. In this study, eight hexahydro‐5H‐isoxazolo[4,5‐f]isoindole‐5,7(6H)‐dione derivatives bearing isoxazole moieties were synthesized and their inhibitory effects on various metabolic enzymes, including acetylcholinesterase (AChE) and human carbonic anhydrase isoforms I and II (hCA I and hCA II), which are associated with global disorders such as Alzheimer's disease (AD), epilepsy, and glaucoma, were investigated. Among the synthesized compounds, derivatives 9--12 exhibited notable inhibitory activity against AChE, hCA I, and hCA II enzymes. The IC50 values were determined to be in the ranges of 4.65--12.83 nM for AChE, 23.17--79.58 nM for hCA I, and 36.58--88.28 nM for hCA II. Molecular docking studies of the synthesized compounds 9a--12a were carried out against three ... |
| Anahtar Kelimeler |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale |
| Dergi Adı | Journal of Biochemical and Molecular Toxicology |
| Dergi ISSN | 1095-6670 Wos Dergi Scopus Dergi |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Dergi Grubu | Q2 |
| Makale Dili | Türkçe |
| Basım Tarihi | 10-2025 |
| Cilt No | 39 |
| Doi Numarası | 10.1002/jbt.70550 |
| Makale Linki | 10.1002/jbt.70550 |
| Atıf Sayıları |
