| Yazarlar (6) |
Suzan Bindal
|
|
Özlem Coşkun
Gazi Üniversitesi, Türkiye |
|
Bülent Alioğlu
Sağlık Bilimleri Üniversitesi, Türkiye |
|
Levent Ertuğrul İnan
Sağlık Bilimleri Üniversitesi, Türkiye |
Dr. Öğr. Üyesi Burç Esra ŞAHİN
Kırşehir Ahi Evran Üniversitesi, Türkiye |
|
Ruhsen Öcal
Sağlık Bilimleri Üniversitesi, Türkiye |
| Özet |
| Background: Cerebral venous thrombosis (CVT) accounts for 0.5% of cerebrovascular diseases (CVDs). A prothrombotic state can be demonstrated in 34% of the affected patients, while 22% of them had a genetic prothrombotic tendency. The main action of plasminogen activator inhibitor (PAI-1) is to regulate the fibrinolytic system. PAI-1 deficiency is associated with abnormal bleeding.Methods: A total of 20 patients were confirmed to have CVT with brain magnetic resonance imaging (MRI) and MR venography, and 26 healthy controls were enrolled in this prospective study.Results: PAI levels were studied in 20 patients who sustained a CVT attack and 26 healthy controls. PAI-1 levels were compared between patients with acute and chronic CVT as well. The mean PAI-1 levels in the healthy controls and patient group were 13.32 (4.58-47.72) and 40.66 (8.75-146.88), respectively. There was a significant difference between both groups with respect to PAI-1 level, with the patient group having a higher PAI-1 level. No significant differences in blood PAI-1 levels were found between acute and chronic CVT.Conclusions: Our study demonstrated that PAI-1 level is a significant risk factor for acute and chronic CVT. In future, reducing PAI-1 levels may determine the treatment approach in CVT patients. |
| Anahtar Kelimeler |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | Uluslararası alan indekslerindeki dergilerde yayınlanan tam makale |
| Dergi Adı | Elmer Press, Inc.- Journal of Neurology Research |
| Dergi ISSN | 1923-2845 |
| Dergi Tarandığı Indeksler | Worldcat; EBSCO; Google Scholar; Google; JournalTOCs; PubMed |
| Makale Dili | İngilizce |
| Basım Tarihi | 04-2018 |
| Cilt No | 8 |
| Sayı | 1 |
| Sayfalar | 4 / 9 |
| Doi Numarası | 10.14740/jnr472w |
| Makale Linki | http://dx.doi.org/10.14740/jnr472w |
| Atıf Sayıları | |
| Google Scholar | 2 |
