| Objectives: This study aims to evaluate the diagnostic value ofcomplete blood count (CBC) parameters in patients with peripheralnerve sheath tumors (PNSTs).Patients and methods: A total of 181 patients (83 males,98 females; median age: 44 years; range, 15 to 83 years)who underwent surgical treatment for PNSTs in our tertiaryoncology center between January 2010 and December 2019 wereretrospectively analyzed. Eighty-two patients were diagnosed witha neurofibroma, 79 with a schwannoma, and 20 with a malignantPNST (MPNST). The patient group was evaluated as malignant(n=20) and benign (n=161). Age- and sex-matched patientsadmitted to our outpatient clinic of orthopedic and traumatologywith non-specific symptoms other than tumor, infection,fracture, and rheumatological or hematological diseases wereincluded as the control group (n=165). Data including age, sex,definitive histopathological diagnosis, and pre-treatment CBCvalues were obtained from the hospital records. Pre-treatmentCBC values such as neutrophil-to-lymphocyte ratio (NLR),platelet-to-lymphocyte ratio (PLR), and lymphocyte-to-monocyteratio (LMR) were calculated for both malignant and benigngroups and control groups. Diagnostic values of NLR, PLR, andLMR between PNST groups were assessed using the receiveroperating characteristic (ROC) curve analysis.Results: Neurofibroma, schwannoma, and MNPST groups hadsignificantly higher median NLR, compared to the control group(p<0.001), while the median LMR was significantly lower inthese groups (p<0.05). However, the median PLR was higher onlyin the MPNST group, compared to the control group (p<0.001).Post-hoc analyses revealed that median NLR, PLR, and LMRratios were similar in PNST groups, compared to the control group.In addition, the median NLR, PLR, and LMR ratios were similarbetween malignant and benign patient groups. The highest areaunder the curve (AUC) was found for NLR (AUC=0.756) and LMR(AUC=0.716) in the MPNST group.Conclusion: Our study results suggest that NLR, PLR, and LMRmay have an added value in the early diagnosis of PNSTs andare valuable for differentiating patients from healthy individuals,although their value in differential diagnosis is still unclear. |
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