| Yazarlar (4) |
Melek Aydin
Kirsehir Ahi Evran University, Türkiye |
Arş. Gör. Nebahat ÇAĞLAYAN
Kırşehir Ahi Evran Üniversitesi, Türkiye |
|
Özlem Kara
Kirsehir Ahi Evran University, Türkiye |
|
Mustafa Kara
Kirsehir Ahi Evran University, Türkiye |
| Özet |
| Sepsis is a serious reaction of the whole body to an infection that develops in the presence of bacteria or toxins in the body. Boric acid (BA) is the most common mineral acid among boron compounds and is easily soluble in water. BA has antioxidant and anti-inflammatory properties. In line with this information, in our study, the protective effect of BA was examined by creating sepsis with lipopolysaccharide (LPS), a bacterial endotoxin. In our study, 32 Wistar Albino female rats were used and divided into four groups. The protective effect of BA on ovarian histopathology and ovarian functions as a result of endotoxaemia was investigated. As a result of the examinations, follicle counts were evaluated in the groups. As a result, it was found that fibrosis occurred in the cortex vessels in the ovary of rats given LPS, follicle loss occurred, and ovarian tissue scarring caused toxicity on primordial follicles. The number of primordial follicles in the LPS group was significantly lower than in the BA + LPS group (p < 0.05). Contrary to this, the number of atretic follicles was found to be significantly higher in the LPS group than in the BA + LPS group (p < 0.05). In this study, it was concluded that BA had a protective effect on the ovarian damage caused by endotoxaemia induced by LPS. |
| Anahtar Kelimeler |
| boric acid | endotoxaemia | infection | ovary | sepsis |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale |
| Dergi Adı | The journal of obstetrics and gynaecology research |
| Dergi ISSN | 1447-0756 Wos Dergi Scopus Dergi |
| Dergi Grubu | Q3 |
| Makale Dili | İngilizce |
| Basım Tarihi | 08-2025 |
| Cilt No | 51 |
| Doi Numarası | 10.1111/jog.70055 |
| Atıf Sayıları |
