Exosome Proteomics of SOD1D90A Mutation Suggest Early Disease Mechanisms, and FN1 as a Biomarker
Yazarlar (7)
Mukesh Gautam Northwestern University Feinberg School Of Medicine, Amerika Birleşik Devletleri
Ali Laith Northwestern University Feinberg School Of Medicine, Amerika Birleşik Devletleri
Prof. Dr. Aslıhan GÜNEL Kırşehir Ahi Evran Üniversitesi, Türkiye
Melda Yilmaz
Kocaeli Üniversitesi, Türkiye
Kocaeli Üniversitesi, Türkiye
Nazli Basak
Koç University, Türkiye
Koç University, Türkiye
Halil Idrisoglu
İstanbul Tıp Fakültesi, Türkiye
İstanbul Tıp Fakültesi, Türkiye
P. Hande Ozdinler Northwestern University Feinberg School Of Medicine, Amerika Birleşik Devletleri
| Makale Türü |
Özgün Makale
(SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale)
|
||
| Dergi Adı | Annals of Clinical and Translational Neurology (Q1) | ||
| Dergi ISSN | 2328-9503 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 09-2025 |
| Cilt / Sayı / Sayfa | 13 / 1 / 131–143 | DOI | 10.1002/acn3.70208 |
| Makale Linki | https://onlinelibrary.wiley.com/doi/epdf/10.1002/acn3.70208 | ||
| UAK Araştırma Alanları |
Genetik
Biyokimya
Moleküler Genetik
|
||
| Özet |
| Amyotrophic lateral sclerosis (ALS) is a neuromuscular disease. Super oxide dismutase 1 (SOD1) gene mutations cause ALS, and the D90A mutation is associated with primarily upper motor neuron (UMN) loss. Objective Our goal is to reveal the early cellular events in ALS pathology and identify potential pharmacokinetic biomarkers, using well‐defined patient populations. Methods Exosomes are isolated from serum either single or multiple time points from members of one family, who have SOD1D90A mutation, and their protein content is assessed by tandem mass‐spec proteomics. Ingenuity Pathway analysis is used to highlight cellular events that are perturbed as the disease progressed. The linear regression analysis, using ALSFRS scores of patients and the protein content, helps identify potential pharmacokinetic biomarkers, which are confirmed with the ELISA assay. Results Father, Son, and Daughter … |
| Anahtar Kelimeler |
| ALS | biomarker | exosomes | proteomics | SOD1 |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Google Scholar | 1 |