Amoxicillin-loaded polycaprolactone-gelatin nanofiber/net (NFN) matrices for pneumothorax treatment
Yazarlar (4)
Arş. Gör. Gökçe MÜLAZIMOĞLU Kırşehir Ahi Evran Üniversitesi, Türkiye
Ülkü Çayır Hacettepe Üniversitesi, Türkiye
Demet Çakır Hacettepe Üniversitesi, Türkiye
Menemşe Gümüşderelioğlu Hacettepe Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | International Journal of Pharmaceutics (Q1) | ||
| Dergi ISSN | 0378-5173 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | Türkçe | Basım Tarihi | 04-2025 |
| Cilt / Sayı / Sayfa | 675 / 1 / – | DOI | 10.1016/j.ijpharm.2025.125525 |
| Makale Linki | https://doi.org/10.1016/j.ijpharm.2025.125525 | ||
| Özet |
| The recurrence rate of spontaneous pneumothorax (collapsed lung) is 30 % after basic conservative treatments, and it can reach up to 20 % after surgery due to the limited effectiveness of current surgical techniques. This highlights the need for the development of new, effective treatment approaches supported by biomaterials. Therefore, we aimed to develop a biomaterial that does not restrict the aerodynamic movements of the lungs, is resistant to lung pressure, and can withstand the movements during inhalation and exhalation,to prevent and treat pneumothorax recurrence. For this purpose, biodegradable matrices were prepared using polycaprolactone (PCL), gelatin (GEL), and amoxicillin (AMX), which is a broad-spectrum antibiotic. The matrices were designed with a nanofiber/net (NFN) structure, targeting appropriate degradation rates and mechanical strength. NFN matrices with randomly arranged and … |
| Anahtar Kelimeler |
| Amoxicillin (AMX) | Electrospinning | Gelatin (GEL) | Nano net | Pneumothorax | Polycaprolactone (PCL) |
Science Direct
Amoxicillin-loaded polycaprolactone-gelatin nanofiber/net (NFN) matrices for pneumothorax treatment
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Scopus | 1 |
| Google Scholar | 1 |