| Yazarlar (6) |
Doç. Dr. Özlem GÜNDOĞDU AYTAÇ
Kırşehir Ahi Evran Üniversitesi, Türkiye |
Hilal Başak Gündoğdu
|
Dr. Öğr. Üyesi Sertan AYTAÇ
Kırşehir Ahi Evran Üniversitesi, Türkiye |
|
Zeynebe Bingöl
Tokat Gaziosmanpaşa Üniversitesi, Türkiye |
|
İlhami Gülçin
Atatürk Üniversitesi, Türkiye |
|
Yunus Kara
Atatürk Üniversitesi, Türkiye |
| Özet |
| It is known that compounds containing isoxazole units exhibit a high potential for biological activity due to the isoxazole ring. In this study, eight hexahydro‐5H‐isoxazolo[4,5‐f]isoindole‐5,7(6H)‐dione derivatives bearing isoxazole moieties were synthesized and their inhibitory effects on various metabolic enzymes, including acetylcholinesterase (AChE) and human carbonic anhydrase isoforms I and II (hCA I and hCA II), which are associated with global disorders such as Alzheimer's disease (AD), epilepsy, and glaucoma, were investigated. Among the synthesized compounds, derivatives 9–12 exhibited notable inhibitory activity against AChE, hCA I, and hCA II enzymes. The IC50 values were determined to be in the ranges of 4.65–12.83 nM for AChE, 23.17–79.58 nM for hCA I, and 36.58–88.28 nM for hCA II. Molecular docking studies of the synthesized compounds 9a–12a were carried out against three … |
| Anahtar Kelimeler |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale |
| Dergi Adı | Journal of Biochemical and Molecular Toxicology |
| Dergi ISSN | 1095-6670 Wos Dergi Scopus Dergi |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Dergi Grubu | Q2 |
| Makale Dili | Türkçe |
| Basım Tarihi | 10-2025 |
| Cilt No | 39 |
| Doi Numarası | 10.1002/jbt.70550 |
| Makale Linki | 10.1002/jbt.70550 |
| Atıf Sayıları |
