Enhancing proteasome activity by NMDAR antagonists explains their therapeutic effect in neurodegenerative and mental diseases.
Yazarlar (9)
Prof. Dr. Fikret Şahin Ankara Üniversitesi, Türkiye
Prof. Dr. Aslıhan GÜNEL Kırşehir Ahi Evran Üniversitesi, Türkiye
Dr. Öğr. Üyesi Buse Türegün Atasoy Ankara Üniversitesi, Türkiye
Dr. Öğr. Üyesi Ülkü Güler Hacettepe Üniversitesi, Türkiye
Prof. Dr. Bekir Salih Hacettepe Üniversitesi, Türkiye
Prof. Dr. Işınsu Kuzu Ankara Üniversitesi, Türkiye
Prof. Dr. Mehmet Taşpınar Aksaray Üniversitesi, Türkiye
Prof. Dr. Özgür Çınar Ankara Üniversitesi, Türkiye
Dr. Öğr. Üyesi Selda Kahveci Ankara Üniversitesi, Türkiye
| Makale Türü |
Özgün Makale
(SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale)
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| Dergi Adı | Scientific Reports (Q1) | ||
| Dergi ISSN | 2045-2322 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | Türkçe | Basım Tarihi | 01-2025 |
| Cilt / Sayı / Sayfa | 15 / 1 / 1165–0 | DOI | 10.1038/s41598-024-84479-w |
| Makale Linki | https://www.nature.com/articles/s41598-024-84479-w#citeas | ||
| UAK Araştırma Alanları |
Biyokimya
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| Özet |
| NMDAR antagonists, such as memantine and ketamine, have shown efficacy in treating neurodegenerative diseases and major depression. The mechanism by which these drugs correct the aforementioned diseases is still unknown. Our study reveals that these antagonists significantly enhance 20S proteasome activity, crucial for degrading intrinsically disordered, oxidatively damaged, or misfolded proteins, factors pivotal in neurodegenerative diseases like Alzheimer’s and Parkinson’s. In our mouse model experiment, ketamine administration notably altered brain synaptic protein profiles within two hours, significantly downregulating proteins strongly associated with Alzheimer’s and Parkinson’s diseases. Furthermore, the altered proteins exhibited enrichment in terms related to plasticity and potentiation, including retrograde endocannabinoid signaling—a pivotal pathway in both short- and long-term plasticity that … |
| Anahtar Kelimeler |
| Mental diseases | N-methyl-D-aspartate receptor (NMDAR) antagonists | Neurodegenerative diseases | Proteasome |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Scopus | 9 |
| Google Scholar | 10 |