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Determination of alterations in protein profiles of brain tissues of experimental epilepsy models by proteome analysis   
Yazarlar (6)
O. Danis
S. Demir
R. Aker
Prof. Dr. Aslıhan GÜNEL Prof. Dr. Aslıhan GÜNEL
F. Onat
A. Ogan
Devamını Göster
Özet
Epilepsy, a chronic disorder characterized by repeated seizures resulting from abnormal activation of neurons in the brain. Although studies defined mutations and polymorphisms in genes related to Na+, K+, Ca++ channels and neuronal signaling in some types of epilepsy, there are few studies showing protein changes. Proteomics technology which has been developed in recent years, can detect the structure, quantity and post-translational changes of proteins in cells and tissues. The difference of this technique from other protein analysis methods is that its ability of high throughput quantitative and qualitative detection of all the proteins in cells or tissues with their post-translational modifications at a given time. In this study we investigated the protein changes in a genetic rat model of absence epilepsy Genetic Absance Epilepsy Rats from Strasbourg (GAERS) with proteomics technology-two dimensional gel …
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