| Yazarlar (2) |
Doç. Dr. Erdoğan SÖKMEN
Kırşehir Ahi Evran Üniversitesi, Türkiye |
Dr. Öğr. Üyesi Muhammet Salih ATEŞ
Kırşehir Ahi Evran Üniversitesi, Türkiye |
| Özet |
| Aim: Previous studies showed that essential hypertension (EHT) had been related to chronic inflammation. A non-dipping circadian blood pressure (BP) pattern confers a greater cardiovascular morbidity and mortality. The multi-inflammatory index (MII) is a novel systemic inflammatory parameter. We aimed to assess the association between MII and the non-dipping BP pattern. Materials and Methods: A total of 158 EHT patients were stratified into nondipper (n=78) and dipper groups (n=80) on the basis of 24h-ambulatory BP monitoring (24h-ABPM). 176 healthy subjects were recruited as control group. Data regarding 24h-ABPM, clinical and laboratory findings were collected from the hospital records. MII was calculated as: Neutrophil count x C-reactive protein/Lymphocyte count. Results: MII was greater in the non-dippers as compared with the dippers and the controls [5.9(1.21-10.1), 3.32(1.34-8.87), and 1.79(0-4.1), respectively, p=0.003]. MII was found to show correlation with age (0.200, p=0.011), 24h-systolic BP 0.234, p=0.003), daytime systolic BP (0.192, p=0.016), nighttime systolic BP (0.277, p<0.001), and LVMI (-0.195, p=0.021). In the multivariate logistic regression model, daytime systolic BP [Odd ratio: 1.171(1.077-1.272, p<0.001] and MII [Odd ratio: 1.150(1.029-1.284), p=0.013] were found to be significantly associated with the non-dipping BP pattern. ROC curve analysis revealed a cut-off value of 2.01 with 71.1% sensitivity and 50.4% specificity for MII to predict the nondippers among the EHT patients. Discussion: MII is significantly associated with nondipping circadian BP pattern. MII could be a simple and useful marker to predict the nondippers among the EHT patients. |
| Anahtar Kelimeler |
| multi-inflammatory index | nondipper hypertension | essential hypertension | inflammation |
| Makale Türü |
Özgün Makale
|
| Makale Alt Türü | ESCI dergilerinde yayınlanan tam makale |
| Dergi Adı | Annals of Clinical and Analytical Medicine |
| Dergi ISSN | 2667-663X Wos Dergi |
| Dergi Tarandığı Indeksler | |
| Makale Dili | İngilizce |
| Basım Tarihi | 01-2025 |
| Cilt No | 16 |
| Sayı | 10 |
| Sayfalar | 705 / 709 |
| DOI Numarası | 10.4328/ACAM.22594 |
| Makale Linki | https://doi.org/10.4328/ACAM.22594 |
| Atıf Sayıları |
